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FLASH GENE

Symbol

MBIP

contributors: KTN/npt - updated : 15/12/2008

HGNC name	MAP3K12 binding inhibitory protein 1
HGNC id	20427

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q13.3      Physical location : 36.767.763 - 36.789.882
Synonym name	MBIP protein
	MAPK upstream kinase-binding inhibitory protein
	MUK-binding inhibitory protein
Synonym symbol(s)	BM-015

DNA

TYPE	functioning gene
STRUCTURE	22.08 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MBIP 9 - 1623 39.1 344 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine thyroid       moderately Lymphoid/Immune lymph node       moderately Respiratory lung       moderately Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a C-terminal half with two leucine zipper-like motifs, which are predicted to form short amphipathic alpha helices, separated by a basic nuclear localization sequence

HOMOLOGY

interspecies	homolog to dog MBIP (91.9 pc)
	homolog to chimpanzee MBIP (99.1 pc)
	homolog to cow MBIP (89.5 pc)
	homolog to rattus Mbip (84.5 pc)
	homolog to murine Mbip (82 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus
text	cytoplasmic localization when co-expressed with MAP3K12

basic FUNCTION	acting as a negative regulator of a MAPKKK-class protein
	inhibiting the MAP3K12 activity to induce the activation of the JNK/SAPK pathway
	playing a role in the inactivation of MAPK activity during osmolarity sensing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with MAP3K12

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in esophageal squamous cell carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS