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FLASH GENE
Symbol MBIP contributors: KTN/npt - updated : 15/12/2008
HGNC name MAP3K12 binding inhibitory protein 1
HGNC id 20427
Location 14q13.3      Physical location : 36.767.763 - 36.789.882
Synonym name
  • MBIP protein
  • MAPK upstream kinase-binding inhibitory protein
  • MUK-binding inhibitory protein
  • Synonym symbol(s) BM-015
    DNA
    TYPE functioning gene
    STRUCTURE 22.08 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0391 14q13.1-q21.2 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like LOC390468 14 similar to Plasmodium falciparum trophozoite antigen r45-like protein LOC390469 14 similar to interleukin enhancer binding factor 2 MBIP 14q13 similar to interleukin enhancer binding factor 2 LOC387985 14 hypothetical gene supported by AY102071 TITF1 14q13.1-q13.2 thyroid transcription factor 1 PHKBP2 14q13.2 phosphorylase kinase, beta pseudogene 2 NKX2-8 14q13.1-p13.2 NK2 transcription factor related, locus 8 (Drosophila) PAX9 14q12-q13.1 paired box gene 9 SLC25A21 14q11.2 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 MIPOL1 14q13.3 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1623 39.1 344 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   moderately
    Lymphoid/Immunelymph node   moderately
    Respiratorylung   moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal half with two leucine zipper-like motifs, which are predicted to form short amphipathic alpha helices, separated by a basic nuclear localization sequence
  • HOMOLOGY
    interspecies homolog to dog MBIP (91.9 pc)
    homolog to chimpanzee MBIP (99.1 pc)
    homolog to cow MBIP (89.5 pc)
    homolog to rattus Mbip (84.5 pc)
    homolog to murine Mbip (82 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text cytoplasmic localization when co-expressed with MAP3K12
    basic FUNCTION
  • acting as a negative regulator of a MAPKKK-class protein
  • inhibiting the MAP3K12 activity to induce the activation of the JNK/SAPK pathway
  • playing a role in the inactivation of MAPK activity during osmolarity sensing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP3K12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in esophageal squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS