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FLASH GENE
Symbol MBIP contributors: KTN/npt - updated : 15/12/2008
HGNC name MAP3K12 binding inhibitory protein 1
HGNC id 20427
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1623 39.1 344 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinethyroid   moderately
Lymphoid/Immunelymph node   moderately
Respiratorylung   moderately
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal half with two leucine zipper-like motifs, which are predicted to form short amphipathic alpha helices, separated by a basic nuclear localization sequence
  • HOMOLOGY
    interspecies homolog to dog MBIP (91.9 pc)
    homolog to chimpanzee MBIP (99.1 pc)
    homolog to cow MBIP (89.5 pc)
    homolog to rattus Mbip (84.5 pc)
    homolog to murine Mbip (82 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text cytoplasmic localization when co-expressed with MAP3K12
    basic FUNCTION
  • acting as a negative regulator of a MAPKKK-class protein
  • inhibiting the MAP3K12 activity to induce the activation of the JNK/SAPK pathway
  • playing a role in the inactivation of MAPK activity during osmolarity sensing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP3K12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in esophageal squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS