basic FUNCTION
| functions to facilitate the specific and efficient activation of the JNK signaling pathways |
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potential scaffolding role for MAPKBP1 in the TRAF2-NR2C2-NF-kappaB signaling pathway |
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contributes to maintain NOD2-mediated intestinal immune homeostasis |
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play a scaffold function in JNK signaling |
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attenuates NOD2-mediated proinflammatory and antibacterial signaling |
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is also able to negatively regulate the antibacterial activity of NOD2 |
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could contribute to NOD2-mediated intestinal immune homeostasis by regulating NOD2-dependent proinflammatory and antibacterial signaling |
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key transcription factor in the NFKB1 signalling pathway |
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is likely the first member of a non-ciliary gene family for NPHP that may account for non-syndromic forms of NPHP for which causative mutated genes remain largely to be identified |