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FLASH GENE
Symbol MAPKBP1 contributors: mct - updated : 14-03-2017
HGNC name mitogen-activated protein kinase binding protein 1
HGNC id 29536
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal 12 WD-40 repeats, necessary for the interaction with NOD2
  • and a JNK-binding region located in the C-terminal region, with several predicted phosphorylation sites and putative protein-binding sequences
  • MAPKBP1 and WDR62 also share a highly conserved C-terminal coiled-coil containing region that is required for WDR62 homodimerization and some evidence indicates that it might also be involved in MAPKBP1-WDR62 heterodimerization
  • HOMOLOGY
    interspecies homolog to mouse Jnkbp1 (85 p100)
    intraspecies paralog to WDR62
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of mitosis where it colocalizes with its paralog WDR62, which plays a key role at MSP
  • basic FUNCTION
  • functions to facilitate the specific and efficient activation of the JNK signaling pathways
  • potential scaffolding role for MAPKBP1 in the TRAF2-NR2C2-NF-kappaB signaling pathway
  • contributes to maintain NOD2-mediated intestinal immune homeostasis
  • play a scaffold function in JNK signaling
  • attenuates NOD2-mediated proinflammatory and antibacterial signaling
  • is also able to negatively regulate the antibacterial activity of NOD2
  • could contribute to NOD2-mediated intestinal immune homeostasis by regulating NOD2-dependent proinflammatory and antibacterial signaling
  • key transcription factor in the NFKB1 signalling pathway
  • is likely the first member of a non-ciliary gene family for NPHP that may account for non-syndromic forms of NPHP for which causative mutated genes remain largely to be identified
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizes and heterodimerizes with WDR62
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPKBP1 interacted with not only NR2C2, but also with its upstream regulators, TNF-receptor associated factors 2 and 6 (TRAF2 and TRAF6)
  • through its WD-40 domain, binds to NOD2 (this interaction attenuates NOD2-mediated NFKB1 activation and IL8 secretion as well as NOD2 antibacterial activity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHP20
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with significantly shorter event-free survival and overall survival in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS