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FLASH GENE
Symbol MAPKAP1 contributors: mct/npt/pgu - updated : 13-02-2013
HGNC name mitogen-activated protein kinase associated protein 1
HGNC id 18752
Location 9q33.3      Physical location : 128.199.673 - 128.469.513
Synonym name
  • ras inhibitor MGC2745
  • SAPK-interacting protein 1
  • MEKK2-interacting protein 1
  • stress-activated map kinase interacting protein 1
  • TORC2 subunit MAPKAP1
  • ras inhibitor MGC2745
  • target of rapamycin complex 2 subunit MAPKAP1
  • Synonym symbol(s) MIP1, SIN1, SIN1b, SIN1g, MGC2745, JC310, MGC2745
    DNA
    TYPE functioning gene
    STRUCTURE 269.84 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ38464 9q34.11 hypothetical protein FLJ38464 KIAA1608 9q34.11 KIAA1608 LHX2 9q33-q34.1 LIM homeobox protein 2 NEK6 9q33.3-q34.11 NIMA (never in mitosis gene a)-related kinase 6 PSMB7 9q33-q34 proteasome (prosome, macropain) subunit, beta type, 7 GPR144 9q34.11 G protein-coupled receptor 144 NR5A1 9q33 nuclear receptor subfamily 5, group A, member 1 NR6A1 9q33-q34.1 nuclear receptor subfamily 6, group A, member 1 LOC169611 9q34.11 hypothetical protein LOC169611 LOC158125 9q34.11 similar to DKFZP434C245 protein RPL35 9q34.1 ribosomal protein L35 ARPC5L 9q34.11 actin related protein 2/3 complex, subunit 5-like GOLGA1 9q34.11 golgi autoantigen, golgin subfamily a, 1 FLJ36664 9q34.11 hypothetical protein FLJ36664 PPP6C Xq22.3 protein phosphatase 6, catalytic subunit NDUFB3P2 9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2 RAB9P40 9q33.1-q33.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2 HSPA5 9q34 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) LOC392393 9 similar to 40S ribosomal protein S10 DKFZP434C212 9q34.11 DKFZP434C212 protein MAPKAP1 9q34.11-q34.12 mitogen-activated protein kinase associated protein 1 LOC51145 9q34.12 erythrocyte transmembrane protein PBX3 9q34.1 pre-B-cell leukemia transcription factor 3 C9orf28 9 chromosome 9 open reading frame 28 LMX1B 9q34.1 LIM homeobox transcription factor 1, beta ZNF297B 9p24.1-q22.33 zinc finger protein 297B RALGPS1A 9q34.11-q34.12 zinc finger protein 297B ANGPTL2 9q34 angiopoietin-like 2 DKFZp761J1523 9q34.13 hypothetical protein DKFZp761J1523 SLC2A8 9q34.1-q34.2 solute carrier family 2, (facilitated glucose transporter) member 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3395 58 522 - 2005 1572220
    variant 1, SIN1, MIP1b
    11 - 3287 54 486 - 2005 1572220
  • variant 2, SIN1b, MIP1a
  • lacking an alternate in frame exon in the 3' coding region as compared to variant 1
  • 11 - 3254 53 475 - 2005 1572220
  • variant 3, SIN1g
  • lacking an alternate in frame exon in the 3' coding region as compared to variant 1
  • 11 - 3067 37 330 - 2005 1572220
  • variant 4, SIN1d
  • lacking an alternate in frame exon in the 5' coding region as compared to variant 1
  • using a downstream start codon
  • 10 - 2977 37 330 - 2005 1572220
  • variant 5, SIN1e
  • lacking two alternate in frame exons in the 5' coding region, as compared to variant 1
  • using a downstream start codon
  • 10 splicing 1593 36 323 - 2005 1572220
  • variant 6, SIN1a
  • differing in the 3' coding region and UTR as compared to variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Raf-like Ras-binding domain (RBD) able to bind activated H-and K-Ras and a pleckstrin homology (PH) domain involved in lipid and membrane binding by MAPKAP1
  • a nuclear localization signal
  • two bipartite nuclear localization signals
  • a peroxisomal targeting signal
  • a PEST motif for rapid protein degradation
  • C-terminus having the pleckstrin homology (PH) domain foldand omparison with known PH-domain structures suggests a putative binding site for phosphoinositides
  • HOMOLOGY
    interspecies homolog to murine Mapkap1 (97.1pc)
    homolog to rattus Mapkap1 (96.9pc)
    ortholog to S.cerevisiae Avo1
    Homologene
    FAMILY
  • SIN1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    basic FUNCTION
  • regulating MEKK2 dimerization and activation by forming a complex with inactive and non-phosphorylated MEKK2
  • maintaining CRTC2 complex integrity and regulating Akt phosphorylation and substrates specificity
  • may act as scaffold molecules in the regulation of signaling by JNK
  • scaffold protein that organizes antiapoptotic responses in stressed cells
  • plays an important role in the SAPK signaling pathway by binding to both ATF 2 and MAPK14
  • may contribute to ATF2 signaling specificity by acting as a nuclear scaffold (Makino 2006)
  • regulates B cell development
  • mediates SGK1 protein interaction with CRTC2 protein complex and is required for selective activation of the epithelial sodium channel
  • serves as a selectivity adaptor for the recruitment of CRTC2 targets
  • plays key roles in the regulation of mitogen-activated protein kinase (MAPK) and MTOR signaling
  • MAPKAP1 and CRTC2 are dispensable for the development and activation of T cells but play a role in natural T-regulatory (nTreg) cells differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    ras pathway
    a component
  • component of CRTC2, a protein kinase complex involved in AKT phosphorylation and cell signaling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MAPK
  • binding to JNK
  • interaction wth RICTOR (with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling)
  • PCBP2, its binding partner, provides for the selective expression of cell survival factors through posttranslational events
  • binds directly to both ATF2 and MAZPK14
  • Ras-inhibitor
  • MAPKAP1/CRTC2-AKT2 signaling axis is a key regulator of FOXO1 transcriptional activity in B cells
  • serves as a selectivity adaptor for the recruitment of CRTC2 targets
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS