Citations for
1CCDC28B, CRTC2, MAPKAP1
The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
Cardenas-Rodriguez M, IrigoĆ­n F, Osborn DP, Gascue C, Katsanis N, Beales PL, Badano JL.
Hum Mol Genet 22(20):4031-42. doi: 10.1093/hmg/ddt253. Epub 2013 May 31. 2013
2MAPKAP1, MTOR, NBN, RICTOR
Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Wang JQ, Chen JH, Chen YC, Chen MY, Hsieh CY, Teng SC, Wu KJ.
PLoS One 8(6):e65586. doi: 10.1371/journal.pone.0065586. Print 2013. 2013
3MAPKAP1
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Pan D, Matsuura Y.
Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 4):386-92. doi: 10.1107/S1744309112007178. Epub 2012 Mar 27. 2012
4CRTC2, MAPKAP1
Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation.
Chang X, Lazorchak AS, Liu D, Su B.
Eur J Immunol 42(6):1639-47. doi: 10.1002/eji.201142066. 2012
5CRTC2, MAPKAP1, SGK1
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Lu M, Wang J, Ives HE, Pearce D.
J Biol Chem 286(35):30647-54. doi: 10.1074/jbc.M111.257592. Epub 2011 Jul 11. 2011
6CRTC2, MAPKAP1
mTORC2 targets AGC kinases through Sin1-dependent recruitment.
Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ.
Biochem J 439(2):287-97. doi: 10.1042/BJ20110678. 2011
7AKT2, CRTC2, MAPKAP1
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
Mol Cell 39(3):433-43. doi: 10.1016/j.molcel.2010.07.031. 2010
8MAPKAP1, PCBP2
A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress.
Ghosh D, Srivastava GP, Xu D, Schulz LC, Roberts RM.
Proc Natl Acad Sci U S A 105(33):11673-8. Epub 2008 Aug 7. 2008
9MAPKAP1
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
Schroder WA, Buck M, Cloonan N, Hancock JF, Suhrbier A, Sculley T, Bushell G.
Cell Signal 19(6):1279-89. Epub 2007 Jan 20. 2007
10MAPKAP1
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM.
Curr Biol 16(18):1865-70. Epub 2006 Aug 17. 2006
11MAPKAP1
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.
Cell 127(1):125-37. Epub 2006 Sep 7. 2006
12CRTC2, RICTOR, MAPKAP1
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Yang Q, Inoki K, Ikenoue T, Guan KL.
Genes Dev 20(20):2820-32. 2006
13AT2, MAPK14, MAPKAP1
Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.
Makino C, Sano Y, Shinagawa T, Millar JB, Ishii S.
Genes Cells 11(11):1239-51. 2006
14MAPKAP1, MAP3K2
Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.
Cheng J, Zhang D, Kim K, Zhao Y, Zhao Y, Su B.
Mol Cell Biol 25(14):5955-64. 2005
15MAPKAP1
The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins.
Schroder W, Bushell G, Sculley T.
Cell Signal 17(6):761-7. Epub 2004 Dec 15. 2005
16MAPKAP1
Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.
Schroder W, Cloonan N, Bushell G, Sculley T.
Gene 339:17-23. 2004