| 1 | CCDC28B, CRTC2, MAPKAP1
|
| The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
|
| Cardenas-Rodriguez M, Irigoín F, Osborn DP, Gascue C, Katsanis N, Beales PL, Badano JL.
|
| Hum Mol Genet 22(20):4031-42. doi: 10.1093/hmg/ddt253. Epub 2013 May 31.
2013
|
| 2 | MAPKAP1, MTOR, NBN, RICTOR
|
| Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
|
| Wang JQ, Chen JH, Chen YC, Chen MY, Hsieh CY, Teng SC, Wu KJ.
|
| PLoS One 8(6):e65586. doi: 10.1371/journal.pone.0065586. Print 2013.
2013
|
| 3 | MAPKAP1
|
| Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
|
| Pan D, Matsuura Y.
|
| Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 4):386-92. doi: 10.1107/S1744309112007178. Epub 2012 Mar 27.
2012
|
| 4 | CRTC2, MAPKAP1
|
| Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation.
|
| Chang X, Lazorchak AS, Liu D, Su B.
|
| Eur J Immunol 42(6):1639-47. doi: 10.1002/eji.201142066.
2012
|
| 5 | CRTC2, MAPKAP1, SGK1
|
| mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
|
| Lu M, Wang J, Ives HE, Pearce D.
|
| J Biol Chem 286(35):30647-54. doi: 10.1074/jbc.M111.257592. Epub 2011 Jul 11.
2011
|
| 6 | CRTC2, MAPKAP1
|
| mTORC2 targets AGC kinases through Sin1-dependent recruitment.
|
| Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ.
|
| Biochem J 439(2):287-97. doi: 10.1042/BJ20110678.
2011
|
| 7 | AKT2, CRTC2, MAPKAP1
|
| Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
|
| Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
|
| Mol Cell 39(3):433-43. doi: 10.1016/j.molcel.2010.07.031.
2010
|
| 8 | MAPKAP1, PCBP2
|
| A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress.
|
| Ghosh D, Srivastava GP, Xu D, Schulz LC, Roberts RM.
|
| Proc Natl Acad Sci U S A 105(33):11673-8. Epub 2008 Aug 7.
2008
|
| 9 | MAPKAP1
|
| Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
|
| Schroder WA, Buck M, Cloonan N, Hancock JF, Suhrbier A, Sculley T, Bushell G.
|
| Cell Signal 19(6):1279-89. Epub 2007 Jan 20.
2007
|
| 10 | MAPKAP1
|
| mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
|
| Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM.
|
| Curr Biol 16(18):1865-70. Epub 2006 Aug 17. 2006
|
| 11 | MAPKAP1
|
| SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
|
| Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.
|
| Cell 127(1):125-37. Epub 2006 Sep 7. 2006
|
| 12 | CRTC2, RICTOR, MAPKAP1
|
| Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
|
| Yang Q, Inoki K, Ikenoue T, Guan KL.
|
| Genes Dev 20(20):2820-32. 2006
|
| 13 | AT2, MAPK14, MAPKAP1
|
| Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.
|
| Makino C, Sano Y, Shinagawa T, Millar JB, Ishii S.
|
| Genes Cells 11(11):1239-51.
2006
|
| 14 | MAPKAP1, MAP3K2
|
| Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.
|
| Cheng J, Zhang D, Kim K, Zhao Y, Zhao Y, Su B.
|
| Mol Cell Biol 25(14):5955-64. 2005
|
| 15 | MAPKAP1
|
| The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins.
|
| Schroder W, Bushell G, Sculley T.
|
| Cell Signal 17(6):761-7. Epub 2004 Dec 15. 2005
|
| 16 | MAPKAP1
|
| Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.
|
| Schroder W, Cloonan N, Bushell G, Sculley T.
|
| Gene 339:17-23. 2004
|