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FLASH GENE
Symbol MAPK8IP1 contributors: mct - updated : 25-03-2019
HGNC name mitogen-activated protein kinase 8 interacting protein 1
HGNC id 6882
Location 11p11.2      Physical location : 45.907.201 - 45.928.015
Synonym name
  • islet-brain 1
  • PRKM8 interacting protein
  • JNK MAP kinase scaffold protein 1
  • C-jun-amino-terminal kinase-interacting protein 1
  • Synonym symbol(s) JIP1, IB1, PRKM8IP, JIP-1
    DNA
    TYPE functioning gene
    STRUCTURE 20.81 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text five splicing variants (Kim)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3079 77.5 711 - 1998 9442013
    - - - - - - 2002 12023290
  • can directly modulate APP metabolism by interacting with the APP cytoplasmic domain, independent of its regulation of the JNK signaling cascade
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus a JUNK binding domain
  • two alpha helical structures
  • two nuclear localization signals (NLS)
  • a proline-rich region
  • an acidic stretch
  • a helix-loop-helix (HLH) domain
  • a phosphotyrosine interacting domain (PID)
  • SH3 homologous region at the C terminus
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine cytoplasmic inhibitor of cJun aminoterminal kinase JIP-1
    homolog to rattus Ib1
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • JIP scaffold family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • regulator of the stress activated protein kinase (MAPK8)
  • regulator or key of beta cell function
  • scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway
  • function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei
  • necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the ABL tyrosine kinase
  • important regulator of axonal development and is a key target of ABL-dependent pathways that control axonal growth
  • because it is involved in regulating cargo binding to kinesin motors, hyperphosphorylated Tau potentially can mediates impaired axonal transport in Alzheimer disease and frontotemporal dementia
  • MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins
  • may be acting as a scaffold protein that mediates JNK activation
  • MAPK8IP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway
  • suppresses NOTCH1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK8 binding
  • suppresses NOTCH1 activity
  • interacting with RBPJ (RBPJ inhibits MAPK8IP1-mediated activation of the MAPK8 signaling cascade and cell death)
  • MAPK8IP1, MAPK8IP3 cooperate to mediate NTRK2 anterograde axonal transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of Mapk8ip1-mediated JNK activation protected the mutant mice against obesity-induced insulin resistance