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FLASH GENE
Symbol MAPK8IP1 contributors: mct - updated : 25-03-2019
HGNC name mitogen-activated protein kinase 8 interacting protein 1
HGNC id 6882
Location 11p11.2      Physical location : 45.907.201 - 45.928.015
Synonym name
  • islet-brain 1
  • PRKM8 interacting protein
  • JNK MAP kinase scaffold protein 1
  • C-jun-amino-terminal kinase-interacting protein 1
  • Synonym symbol(s) JIP1, IB1, PRKM8IP, JIP-1
    DNA
    TYPE functioning gene
    STRUCTURE 20.81 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390111 11 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) KAI1 11p11.2-p11.13 kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) LOC387764 11 LOC387764 LOC90139 11p11.2 tetraspanin similiar to uroplakin 1 TP53I11 11pter-p15.5 tumor protein p53 inducible protein 11 PRDM11 11p11 PR domain containing 11 LOC219638 11p11.2 similar to KIAA0543 protein SYT13 11p12-p11 synaptotagmin XIII CHST1 11p11.2-p11.1 carbohydrate (keratan sulfate GAL-6) sulfotransferase 1 DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain
    RNA
    TRANSCRIPTS type messenger
    text five splicing variants (Kim)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3079 77.5 711 - 1998 9442013
    - - - - - - 2002 12023290
  • can directly modulate APP metabolism by interacting with the APP cytoplasmic domain, independent of its regulation of the JNK signaling cascade
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus a JUNK binding domain
  • two alpha helical structures
  • two nuclear localization signals (NLS)
  • a proline-rich region
  • an acidic stretch
  • a helix-loop-helix (HLH) domain
  • a phosphotyrosine interacting domain (PID)
  • SH3 homologous region at the C terminus
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine cytoplasmic inhibitor of cJun aminoterminal kinase JIP-1
    homolog to rattus Ib1
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • JIP scaffold family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • regulator of the stress activated protein kinase (MAPK8)
  • regulator or key of beta cell function
  • scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway
  • function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei
  • necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the ABL tyrosine kinase
  • important regulator of axonal development and is a key target of ABL-dependent pathways that control axonal growth
  • because it is involved in regulating cargo binding to kinesin motors, hyperphosphorylated Tau potentially can mediates impaired axonal transport in Alzheimer disease and frontotemporal dementia
  • MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins
  • may be acting as a scaffold protein that mediates JNK activation
  • MAPK8IP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway
  • suppresses NOTCH1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK8 binding
  • suppresses NOTCH1 activity
  • interacting with RBPJ (RBPJ inhibits MAPK8IP1-mediated activation of the MAPK8 signaling cascade and cell death)
  • MAPK8IP1, MAPK8IP3 cooperate to mediate NTRK2 anterograde axonal transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of Mapk8ip1-mediated JNK activation protected the mutant mice against obesity-induced insulin resistance