Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAPK8IP1 contributors: mct - updated : 25-03-2019
HGNC name mitogen-activated protein kinase 8 interacting protein 1
HGNC id 6882
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus a JUNK binding domain
  • two alpha helical structures
  • two nuclear localization signals (NLS)
  • a proline-rich region
  • an acidic stretch
  • a helix-loop-helix (HLH) domain
  • a phosphotyrosine interacting domain (PID)
  • SH3 homologous region at the C terminus
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine cytoplasmic inhibitor of cJun aminoterminal kinase JIP-1
    homolog to rattus Ib1
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • JIP scaffold family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • regulator of the stress activated protein kinase (MAPK8)
  • regulator or key of beta cell function
  • scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway
  • function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei
  • necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the ABL tyrosine kinase
  • important regulator of axonal development and is a key target of ABL-dependent pathways that control axonal growth
  • because it is involved in regulating cargo binding to kinesin motors, hyperphosphorylated Tau potentially can mediates impaired axonal transport in Alzheimer disease and frontotemporal dementia
  • MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins
  • may be acting as a scaffold protein that mediates JNK activation
  • MAPK8IP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway
  • suppresses NOTCH1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK8 binding
  • suppresses NOTCH1 activity
  • interacting with RBPJ (RBPJ inhibits MAPK8IP1-mediated activation of the MAPK8 signaling cascade and cell death)
  • MAPK8IP1, MAPK8IP3 cooperate to mediate NTRK2 anterograde axonal transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of Mapk8ip1-mediated JNK activation protected the mutant mice against obesity-induced insulin resistance