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FLASH GENE

Symbol

MAPK12

contributors: - updated : 13-01-2007

HGNC name	mitogen-activated protein kinase 12
HGNC id	6874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.33      Physical location : 50.691.330 - 50.700.089
Synonym name	stress-activated protein kinase 3
	mitogen-activated protein kinase 3
	mitogen-activated protein kinase p38 gamma
Synonym symbol(s)	MAPKK6, SAPK3, ERK6, p38gamma, PRKM12, SAPK-3, ERK3
EC.number	2.7.11.24

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	two shorter forms missing the phosphorylation motif

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Muscular striatum cardiac   highly

cell lineage
cell lines	muscle cell line C2C12
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	KIM domains
	a protein kinase domain
	three PDZ domain-containing binding partners, LIN7C, SCRIB, and outer membrane protein 25 (OMP25)
	C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates SNTA1 and SAP90/PSD95

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

mitogen-activated protein kinase (MAPK) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	phosphorylating enzyme for ELK1, ATF2 and others
	functioning as a signal transducer during differentiation of myoblasts to myotubes
	may inhibit cell proliferation while promoting differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

phosphotyrosine mediated pathway

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 2 magnesium ions

protein	interacts with the PDZ domain of the syntrophin SNTA1
	interacts with SH3BP5

cell & other

REGULATION

activated by	MAP2K3,MAP2K6
	CD14 and LBP
	phosphorylation on threonine and tyrosine

induced by

proinflammatory cytokines,environmental stress

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in myoblast that exhibit an attenuated fusion capacity

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS