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FLASH GENE
Symbol MAPK12 contributors: - updated : 13-01-2007
HGNC name mitogen-activated protein kinase 12
HGNC id 6874
RNA
TRANSCRIPTS type messenger
text two shorter forms missing the phosphorylation motif
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
Muscularstriatumcardiac highly
cell lineage
cell lines muscle cell line C2C12
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • KIM domains
  • a protein kinase domain
  • three PDZ domain-containing binding partners, LIN7C, SCRIB, and outer membrane protein 25 (OMP25)
  • C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates SNTA1 and SAP90/PSD95
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY mitogen-activated protein kinase (MAPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • phosphorylating enzyme for ELK1, ATF2 and others
  • functioning as a signal transducer during differentiation of myoblasts to myotubes
  • may inhibit cell proliferation while promoting differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    phosphotyrosine mediated pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 magnesium ions
    protein
  • interacts with the PDZ domain of the syntrophin SNTA1
  • interacts with SH3BP5
  • cell & other
    REGULATION
    activated by MAP2K3,MAP2K6
    CD14 and LBP
    phosphorylation on threonine and tyrosine
    induced by proinflammatory cytokines,environmental stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in myoblast that exhibit an attenuated fusion capacity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS