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FLASH GENE
Symbol MAP1B contributors: mct/shn - updated : 23-02-2015
HGNC name microtubule-associated protein 1B
HGNC id 6836
Location 5q13.2      Physical location : 71.403.117 - 71.505.396
Synonym name
  • FUTSCH, DROSOPHILA, HOMOLOG OF
  • FUTSCH
  • Synonym symbol(s) MAP5, FLJ38954, FUTSCH, DKFZp686E1099; DKFZp686F1345
    DNA
    TYPE functioning gene
    STRUCTURE 102.28 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D5S637 - D5S1491 - MAP1B - D5S650 - D5S357 - qter
    Physical map
    KENAE 5q13.1 Kenae LOC285653 5q13.1 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein TAF9 5q12 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa RAD17 5q12-q13.1 RAD17 homolog (S. pombe) FLJ30532 5q13.1 hypothetical protein FLJ30532 OCLN 5q13.1 occludin GTF2H2 5q13.1 general transcription factor IIH, polypeptide 2, 44kDa BIRC1 5q13.1 baculoviral IAP repeat-containing 1 SMN1 5q13.1 survival of motor neuron 1, telomeric LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein) LOC389298 5 similar to bA110H4.2 (similar to membrane protein) LOC389299 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC391794 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 PMCHL2 5q13 pro-melanin-concentrating hormone-like 2 BDP1 5q13 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB MCCC2 5q12-q13 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) CART 5q13.1 Homo sapiens cocaine- and amphetamine-regulated transcript (CART), mRNA. MAP1B 5q13 microtubule-associated protein 1B MRPS27 5q13.2 mitochondrial ribosomal protein S27 FLJ12598 5q13.2 hypothetical protein FLJ12598 LOC391795 5 similar to ribosomal protein L10a ZNF366 5q13.1 zinc finger protein 366 LOC389300 5 LOC389300 KPNB2 5p14.2-q22.3 karyopherin (importin) beta 2 LOC115548 5q13.2 hypothetical protein BC014311 LOC134285 5q13.3 hypothetical protein LOC134285 MGC13034 5q13.3 hypothetical protein MGC13034 LOC389301 5 similar to nonhistone chromosomal protein HMG-17 - rat LOC389302 5 LOC389302 FOXD1 5q12-q13 forkhead box D1 BTF3 5p13.2 basic transcription factor 3 LOC220793 5q13.3 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 ANKRA2 5q12-q13 ankyrin repeat, family A (RFXANK-like), 2 FLJ12787 5q13.3 hypothetical protein FLJ12787 PRO1942 5q13.3 hypothetical protein PRO1942 RGNEF 5q13.3 Rho-guanine nucleotide exchange factor ENC1 5q12-q13.3 ectodermal-neural cortex (with BTB-like domain) HEXB 5q12 hexosaminidase B (beta polypeptide) EFG2 5q13 hexosaminidase B (beta polypeptide) TINP1 5q13.3 TGF beta-inducible nuclear protein 1 KIAA0888 5q13.3 KIAA0888 protein LOC260421 5q13 actin related protein 2/3 complex subunit 1A pseudogene LOC389303 5 hypothetical gene supported by BC039003
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 11996 - 2468 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiensAdult
     brainlimbic systemhippocampus   Homo sapiensAdult
    Reproductivemale systemprostate  highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralgray matter predominantly Homo sapiensAdult
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensAdult
    Visualbipolar cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text prominently expressed during early stages of neuronal development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    MAP1B heavy chain and light chain LC1
    secondary structure three ligh chains LC1, LC2, LC3
    HOMOLOGY
    interspecies ortholog to Map1b, Rattus norvegicus
    ortholog to MAP1B, Pan troglodytes
    ortholog to map1b, Danio rerio
    ortholog to Mtap1b, Mus musculus
    Homologene
    FAMILY microtubule associated protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text coexpressed with GABRR1
    basic FUNCTION
  • microtubule associated protein, involved in neurite outgrow
  • involved in the regulation of retrograde axonal transport of mitochondria
  • role in adapting microtubules for nerve cell-specific functions
  • plays a crucial role in cytoskeleton stability and may also have a role in other cellular functions
  • MAP1B-LC1 represses the transcriptional activity of TP53
  • contributes to the maintenance of microtubule dynamics
  • involved in microtubule assembly, an essential step in neurogenesis
  • implicated in regulating microtubule organization and
  • dynamics and neuronal polarization
  • MAP1B RNA forms an intramolecular G quadruplex structure, which is bound with high affinity and specificity by the FMR1 RGG box
  • could be considered as a new protein involved in the terminal differentiation of odontoblasts
  • new and crucial function of MAP1B required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization
  • implicated in axonal growth and guidance
  • new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton
  • this activity of MAP1B could contribute to the regulation of synaptic activity and plasticity in the adult brain
  • have important roles in neuronal development, particularly during neuronal migration and axonogenesis
  • function of MAP1B is to suppress axon branching and enhance axon growth and that this is achieved by maintaining dynamic microtubule growth
  • plays an important role in the stability of the cytoskeleton and may have other cellular functions
  • neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments
  • novel function of MAP1B related with the control of small GTPases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein complex that consists of a heavy chain and light chain (LC1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FMR1 (RNA target of FMR1)
  • PAFAH1B1 and participate in neuronal migration
  • myelin-associated glycoprotein (MAG) and stathmin-like 2 (STMN2)
  • glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  • MAP1B-LC1 an interacting partner of PES1 required for ribosome biogenesis and cell proliferation
  • Mapmodulin/leucine-rich acidic nuclear protein (ANP32A)
  • GABA(C) rho1 subunit
  • gigaxonin (GAN)
  • myelin-associated glycoprotein (MAG)
  • synuclein, alpha (SNCA)
  • Ras association (RalGDS/AF-6) domain family member 1 (RASSF1)
  • MAP1B, a microtubule stabilizing protein, and CLTC, the major component of the clathrin triskelion, are interaction partners for DST
  • may contribute to the spatiotemporal activation of the Rho-GTPases in dendritic spines by binding to the RAC1 and RhoA GEFs, TIAM1, and ARHGEF2
  • MARCH5 interacts with and ubiquitinates mitochondrial MAP1B LC1
  • MAP1B facilitates trafficking of SCNA8 to the neuronal cell surface
  • MAP1B interaction with the FW Domain of the autophagic receptor NBR1 facilitates its Association to the microtubule network
  • MAP1A and MAP1B interact with SNTA1 in the central and peripheral nervous system
  • interacts with a guanine exchange factor, termed TIAM1, which specifically activates RAC1
  • MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway
  • cell & other
    REGULATION
    repressed by FMR1 (inhibition of microtubule -dependent synaptic growth and function)
    Other mitogen-activated protein kinase 8 (MAPK8) a critical regulator of MAP1B activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice carrying an insertion in Mtap1b gene die during embryogenesis. Heterozygotes mice exhibit slower growth rates, lack of visual acuity in one or both eyes, and motor system abnormalities. Histochemical analysis revealed abnormalities in Purkinje cell dendritic processes