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FLASH GENE
Symbol MAGT1 contributors: mct/npt/pgu - updated : 12-10-2017
HGNC name magnesium transporter 1
HGNC id 28880
Corresponding disease
MRX95 mental retardation, X-linked 95
XMEN immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia
Location Xq21.1      Physical location : 77.081.863 - 77.151.065
Synonym name
  • implantation-associated protein
  • oligosaccharyltransferase 3B
  • Synonym symbol(s) FLJ14726, IAP, MGC64926, OST3B, PRO0756, bA217H1.1, DKFZp564K142, IAG2, IAP, MRX95, XMEN
    DNA
    TYPE functioning gene
    STRUCTURE 69.20 kb     10 Exon(s)
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4035 38 335 - 2005 15804357
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lumenally oriented active site CVVC motif in MAGT1 is required for glycosylation of STT3B-dependent acceptor sites including those that are closely bracketed by disulfides or contain cysteine as the internal residue
  • HOMOLOGY
    interspecies ortholog to yeast Ost6
    Homologene
    FAMILY
  • OST3/OST6 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • is at the plasma membrane, but the N terminus is extracellular
  • basic FUNCTION
  • catalyzes the cotranslational transfer of high-mannose sugars to nascent polypeptides during N-linked glycosylation in the rough endoplasmic reticulum lumen
  • may provide a selective and regulated pathway for Mg2+ transport in epithelial cells
  • required for cellular Mg2+ uptake
  • play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
  • MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
  • signaling role for MAGT1 has been proven in T lymphocytes, where Mg(2+) functions as a second messenger, coupling TCR activation to intracellular effectors
  • Mg and MAGT1 play an important role in osteogenic differentiation and may be likely involved in the bone regeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MAGT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX95 , XMEN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression levels of MAGT1 in Hepatocellular carcinoma (HCC) may be potential biomarkers for the diagnosis and prognosis of this cancer
  • Therapy target
    ANIMAL & CELL MODELS