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FLASH GENE
Symbol MAGT1 contributors: mct/npt/pgu - updated : 12-10-2017
HGNC name magnesium transporter 1
HGNC id 28880
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4035 38 335 - 2005 15804357
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineadrenal gland   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lumenally oriented active site CVVC motif in MAGT1 is required for glycosylation of STT3B-dependent acceptor sites including those that are closely bracketed by disulfides or contain cysteine as the internal residue
  • HOMOLOGY
    interspecies ortholog to yeast Ost6
    Homologene
    FAMILY
  • OST3/OST6 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • is at the plasma membrane, but the N terminus is extracellular
  • basic FUNCTION
  • catalyzes the cotranslational transfer of high-mannose sugars to nascent polypeptides during N-linked glycosylation in the rough endoplasmic reticulum lumen
  • may provide a selective and regulated pathway for Mg2+ transport in epithelial cells
  • required for cellular Mg2+ uptake
  • play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
  • MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
  • signaling role for MAGT1 has been proven in T lymphocytes, where Mg(2+) functions as a second messenger, coupling TCR activation to intracellular effectors
  • Mg and MAGT1 play an important role in osteogenic differentiation and may be likely involved in the bone regeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MAGT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX95 , XMEN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression levels of MAGT1 in Hepatocellular carcinoma (HCC) may be potential biomarkers for the diagnosis and prognosis of this cancer
  • Therapy target
    ANIMAL & CELL MODELS