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FLASH GENE
Symbol M6PR contributors: - updated : 08-03-2006
HGNC name mannose-6-phosphate receptor (cation dependent)
HGNC id 6752
Location 12p13.2      Physical location : 9.092.964 - 9.102.252
Synonym name 46-kDa mannose 6-phosphate receptor
Synonym symbol(s) MPR1, CD-MPR, MPR46, SMPR
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
APOBEC1 12p13.2-p13.1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 GDF3 12p13.1 growth differentiation factor 3 LOC338759 12p13.31 STELLA CLECSF11 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 LOC360030 12p13.31 homeobox C14 NANOG 12p13.31 Nanog homeobox SLC2A14 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein CLECSF6 12p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 LOC283321 12p13.31 hypothetical LOC283321 LOC387828 12 LOC387828 FLJ10408 12p13.31 hypothetical protein FLJ10408 LOC387829 12 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC387830 12 similar to CG7889-PA LOC93320 12p13.31 similar to Alkaline sphingomyelinase LOC387831 12 hypothetical gene supported by AK074886 LOC390287 12 hypothetical gene supported by AK122996 LOC390288 12 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC390289 12 similar to seven transmembrane helix receptor LOC341306 12p13.31 similar to 60S ribosomal protein L15 CLECSF8 12p13.31 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 CLECSF9 12p13.32 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 AICDA 12p13 activation-induced cytidine deaminase LOC94468 12p13.31 similar to 78 kDa gastrin-binding protein MAGP2 12p13.1-p12.2 similar to 78 kDa gastrin-binding protein KIAA1238 12p13.31 similar to 78 kDa gastrin-binding protein FLJ25179 12p13.31 hypothetical protein FLJ25179 PHC1 12p13 polyhomeotic-like 1 (Drosophila) M6PR 12p13.2 mannose-6-phosphate receptor (cation dependent) KLRG1 12p13.2-p13.1 killer cell lectin-like receptor subfamily G, member 1 LOC390290 12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC390291 12 similar to voltage-dependent anion channel isoform 2 MGC40170 12p13.31 hypothetical protein MGC40170 A2M 12p13.2-p13.1 alpha-2-macroglobulin PZP 12p13.2-p13.1 pregnancy-zone protein A2MP 12p13.2-p13.1 alpha-2-macroglobulin pseudogene PTMAP4 12p13.31 prothymosin, alpha pseudogene 4 (gene sequence 112) LOC387832 12 similar to helicase LOC387833 12 LOC387833 LOC387834 12 similar to DKFZp434C0631 protein LOC338812 12p13.31 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box-11 (CHL1-related helicase gene-1); yeast CHL1 homolog LOC347939 12p13.31 similar to Ran-GTP binding protein; RanBP6 LOC390292 12 similar to ovomacroglobulin, ovostatin KLRB1 12p13.1-p12.3 killer cell lectin-like receptor subfamily B, member 1 LOC374443 12p13.31 CLR pseudogene LLT1 12p13 CLR pseudogene LOC387835 12 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 DCAL1 12p13.31 dendritic cell-associated lectin-1 CD69 12p13.2-p13.1 CD69 antigen (p60, early T-cell activation antigen) LOC390293 12 similar to ACRC protein; putative nuclear protein KLRF1 12p13.3-p13.2 killer cell lectin-like receptor subfamily F, member 1 CLECSF2 12p13.2-p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) LOC387836 12 similar to INPE5792 CLL-1 CLEC2 12p13.31 C-type lectin-like receptor-2 LOC387837 12 similar to macrophage antigen h LOC283420 12p13.31 similar to HEEE9341 CLEC1 12p13.31 C-type lectin-like receptor-1 LOC390294 12 similar to HNRPAB protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivefemale systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine M6pr
ortholog to rattus m6pr
Homologene
FAMILY Cation-dependent mannose-6-phosphate receptor family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,organelle,lysosome
text type 1 membrane protein
basic FUNCTION
  • mannose 6-phosphate receptor, cation dependent, targeting phosphorylated enzymes to lysosomes
  • involved in transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface
  • to lysosomes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of cell surface of Golgi and late endosome membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding GGA1, GGA2 and GGA3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS