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FLASH GENE
Symbol M6PR contributors: mct - updated : 30-05-2023
HGNC name mannose-6-phosphate receptor (cation dependent)
HGNC id 6752
Location 12p13.31      Physical location : 9.092.964 - 9.102.252
Synonym name
  • 46-kDa mannose 6-phosphate receptor
  • small mannose 6-phosphate receptor
  • cation-dependent mannose-6-phosphate receptor
  • Synonym symbol(s) MPR1, CD-MPR, MPR46, SMPR, CD-M6PR, MPR 46, MPR-46, FLJ32994
    DNA
    TYPE functioning gene
    STRUCTURE 9.28 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2322 - 105 - 1995 7640295
    7 - 2432 - 159 - 1995 7640295
    7 - 2481 - 132 - 1995 7640295
    6 - 2283 - 159 - 1995 7640295
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine M6pr
    ortholog to rattus m6pr
    Homologene
    FAMILY Cation-dependent mannose-6-phosphate receptor family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nuclear envelope
    text type 1 membrane protein
    basic FUNCTION
  • mannose 6-phosphate receptor, cation dependent, targeting phosphorylated enzymes to lysosomes
  • involved in transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface
  • to lysosomes
  • selective M6PR down-regulation has a critical role in CD8(+) T cell survival
  • facilitates cellular uptake of M6P-bearing proteins, including serine-protease granzyme-B (Gzm-B) and has an important role in T-cell activation, migration and contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of cell surface of Golgi and late endosome membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding GGA1, GGA2 and GGA3
  • OCRL counteracted accumulation of M6PR in endosomes in an activity-dependent manner
  • RAB29 is essential for the integrity of the TGN and participates in the retrograde trafficking of M6PR
  • MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
  • HSPA1A and M6PR negatively regulated APP processing and Abeta production
  • GIMAP5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4
  • GIMAP5 promotes the degradation of Respiratory syncytial virus (RSV) and its receptor through interacting with M6PR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS