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FLASH GENE
Symbol LSS contributors: mlc - updated : 05-01-2008
HGNC name lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
HGNC id 6708
Location 21q22.3      Physical location : 47.608.360 - 47.648.738
Synonym name
  • 2,3-epoxysqualene--lanosterol cyclase
  • oxidosqualene cyclase
    • Synonym symbol(s) OSC
    EC.number 5.4.99.7
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - COL18A1 - SLC19A1 - D21S91 - D21S544 - D21S112 - COL6A1 - LSS - COL6A2 - PCNT2 - D21S1446 - S100B - D21S1575 - HRMT1L1
    Authors Lapenta (98)
    Physical map
    LOC391283 21 similar to interspersed repeat antigen, putative C21orf122 21q22.3 chromosome 21 open reading frame 122 ADARB1 21q22.3 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) C21orf89 21q22.1 chromosome 21 open reading frame 89 C21orf80 21q22.3 chromosome 21 open reading frame 80 C21orf86 21q22.1 chromosome 21 open reading frame 86 C21orf93 21q22.1 chromosome 21 open reading frame 93 LOC388830 21 similar to PRED59 COL18A1 21q22.3 collagen, type XVIII, alpha 1 LOC388831 21 LOC388831 SLC19A1 21q22.3 solute carrier family 19 (folate transporter), member 1 LOC388832 21 hypothetical gene supported by BC020585 LOC388833 21 LOC388833 PCBP3 21q22.3 poly(rC) binding protein 3 COL6A1 21q22.3 collagen, type VI, alpha 1 LOC200292 21q22.3 hypothetical LOC200292 COL6A2 21q22.3 collagen, type VI, alpha 2 FTCD 21q22.3 formiminotransferase cyclodeaminase C21orf56 21q22.3 chromosome 21 open reading frame 56 LSS 21q22.3 lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) MCM3APAS 21q22.3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein, antisense C21orf85 21q22.1 chromosome 21 open reading frame 85 MCM3AP 21q22.3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein C21orf57 21q22.3 chromosome 21 open reading frame 57 C21orf58 21q22.3 chromosome 21 open reading frame 58 PCNT2 21q22.3 pericentrin 2 (kendrin) LOC388834 21 hypothetical gene supported by AK127572 C21orf106 21q22.3 chromosome 21 open reading frame 106 S100B 21q22.3 S100 calcium binding protein, beta (neural) HRMT1L1 21q22.3 HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae) RPL23AP4 21q22.3 ribosomal protein L23a pseudogene 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4225 - 732 - Ma (2007)
    23 - 2658 - 732 - Ma (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		four PTFB repeats
    HOMOLOGY
    Homologene
    FAMILY terpene cyclase/mutase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • lanosterol synthase catalyzing cyclization of squalene-2,3-epoxide to lanosterol (biosynthesis of cholesterol, steroid hormones, and vitamin D)
  • catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by HDAC3 (represses transcription from the lanosterol synthase promoter)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS