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FLASH GENE
Symbol LHX4 contributors: mct/npt - updated : 26-08-2008
HGNC name LIM homeobox 4
HGNC id 21734
Corresponding disease
DEL1QM chromosome 1q interstitial deletions
PCDST pituitary and cerebellar defects and small sella turcica
Location 1q25.2      Physical location : 180.199.441 - 180.244.188
Synonym name LIM homeobox protein 4
Synonym symbol(s) Gsh-4, Gsh4
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 44.00 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RGPR 1q24.2-q25.2 regulator of G-protein signalling 16 LOC391141 1 similar to Quinone oxidoreductase (NADPH:quinone reductase) (Zeta-crystallin) RASAL2 1q25 RAS protein activator like 2 DKFZP564J047 1q24.3 hypothetical protein DKFZp564J047 FLJ10244 1q24.3 Ral-A exchange factor RalGPS2 ANGPTL1 1q24.2 angiopoietin-like 1 FAM20B 1q25 family with sequence similarity 20, member B TOR3A 1q24.2-q24.3 torsin family 3, member A ABL2 1q24-q25 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) SOAT1 1q25 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 FLJ32940 1q24.3 hypothetical protein FLJ32940 NPHS2 1q25-q31 nephrosis 2, idiopathic, steroid-resistant (podocin) LOC126860 1q24.3 similar to centaurin, gamma 2 TDRD5 1q24.2 tudor domain containing 5 MGC16664 1q25.1 hypothetical protein MGC16664 LOC163590 1q25.1 AF464140 IFRG15 1q25.1 IFRG15 protein LAP1B 1q24.2 lamina-associated polypeptide 1B CAP350 1p36.13-q41 lamina-associated polypeptide 1B QSCN6 1q24 quiescin Q6 FLJ23867 1q25.1 hypothetical protein FLJ23867 LHX4 1q24.1-q24.3 LIM homeobox 4 LOC388717 1 LOC388717 ACBD6 1q25.1 acyl-Coenzyme A binding domain containing 6 XPR1 1q25 xenotropic and polytropic retrovirus receptor KIAA1614 1q25.1 KIAA1614 protein LOC391142 1 hypothetical gene supported by AJ249778; NM_001531 STX6 1p36 syntaxin 6 MR1 1q25.3 major histocompatibility complex, class I-related IER5 1q25.1 immediate early response 5 LOC284646 1q25.1 hypothetical gene supported by BC039493 CACNA1E 1q25-q31 calcium channel, voltage-dependent, alpha 1E subunit LOC127665 1q25.2 similar to zinc finger protein 135 (clone pHZ-17); zinc finger protein 61 LOC388718 1 similar to Protein translation factor SUI1 homolog (Sui1iso1) GLUL 1q31 glutamate-ammonia ligase (glutamine synthase) HE9 1q25.2 putative membrane protein HE9 LOC388719 1 hypothetical gene supported by AF508909 LOC127671 1q25.2 similar to CE9 protein RGSL2 1q25.2 regulator of G-protein signalling like 2 RGSL1  regulator of G-protein signalling like 1 RNASEL 1q25 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) RGS16 1q25-q31 regulator of G-protein signalling 16
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1913 - 390 - Castinetti (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex  
 spinal cord    
Reproductivefemale systemuterus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text in the spinal cord and hindbrain, Rathke pouch at the early stage of development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two amino terminal tandemly repeated LIM motifs
  • a C terminus helix-turn-helix (homeodomain) binding domain
  • HOMOLOGY
    interspecies ortholog to murine Lhx4
    intraspecies paralog to LHX3
    Homologene
    FAMILY
  • LIM-homeobox gene family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • LIM homeodomain transcription factor involved in pituitary ontogenesis
  • play essential roles in pituitary gland and nervous system development (Mullen 2007)
  • coordinating brain development and skull morphogenesis
  • transactivator of pituitary genes
  • playing a critical role in the development of motor neurons and in specification and expansion of specialized anterior pituitary cells
  • may be playing an important role, possibly as an activator, in leukemogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • morphogenetic organizer of cephalic development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLB
  • LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, (LHX4 expression increased in adult liver in a manner that parallel AFP repression) suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDST , DEL1QM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    in t(1;14) (q25;q32) with IGHG1/LHX4 fusion gene in pre-acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    cooperating with Lhx3 in pituitary development and motor neuron specification in mice