Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LHX4 contributors: mct/npt - updated : 26-08-2008
HGNC name LIM homeobox 4
HGNC id 21734
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex  
 spinal cord    
Reproductivefemale systemuterus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text in the spinal cord and hindbrain, Rathke pouch at the early stage of development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two amino terminal tandemly repeated LIM motifs
  • a C terminus helix-turn-helix (homeodomain) binding domain
  • HOMOLOGY
    interspecies ortholog to murine Lhx4
    intraspecies paralog to LHX3
    Homologene
    FAMILY
  • LIM-homeobox gene family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • LIM homeodomain transcription factor involved in pituitary ontogenesis
  • play essential roles in pituitary gland and nervous system development (Mullen 2007)
  • coordinating brain development and skull morphogenesis
  • transactivator of pituitary genes
  • playing a critical role in the development of motor neurons and in specification and expansion of specialized anterior pituitary cells
  • may be playing an important role, possibly as an activator, in leukemogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • morphogenetic organizer of cephalic development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLB
  • LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, (LHX4 expression increased in adult liver in a manner that parallel AFP repression) suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDST , DEL1QM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    in t(1;14) (q25;q32) with IGHG1/LHX4 fusion gene in pre-acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    cooperating with Lhx3 in pituitary development and motor neuron specification in mice