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FLASH GENE
Symbol LFNG contributors: SGE/npt - updated : 16-10-2009
HGNC name LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
HGNC id 6560
Corresponding disease
SCDO3 spondylocostal dysostosis type 3
Location 7p22.2      Physical location : 2.552.162 - 2.568.808
Synonym name
  • beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
  • lunatic fringe homolog (Drosophila)
  • LFNG O-fucosylpeptide
  • Synonym symbol(s) EVI72
    EC.number 2.4.1.222
    DNA
    TYPE functioning gene
    STRUCTURE 9.33 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    FGL2 7q11.2 fibrinogen-like 2 LOC392930 7 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) KIAA1950 7p22.3 KIAA1950 protein LOC393078 7 similar to polycystic kidney disease 1-like 3 SVH 7q22.1 SVH protein LOC392620 7 LOC392620 GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 EIF3S9 7p22.3 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa NAPE-PLD 7q22.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D LOC392851 7 hypothetical gene supported by AK098637 LOC54103 7q21.11 hypothetical protein LOC54103 ZFD25 7q11.2 hypothetical protein LOC54103 PTPRN2 7q36 protein tyrosine phosphatase, receptor type, N polypeptide 2 CHST12 7p22 carbohydrate (chondroitin 4) sulfotransferase 12 LOC392968 7 similar to 60S ribosomal protein L23a LOC392943 7 similar to hypothetical protein FLJ36166 7q22.1 hypothetical protein FLJ36166 LOC392700 7 similar to myelin protein zero-like 1; protein zero related LOC391995 7 similar to galectin-related inter-fiber protein ZNF138 7q11.21-q11.23 zinc finger protein 138 (clone pHZ-32) LOC392969 7 similar to Putative S100 calcium-binding protein A11 pseudogene LFNG 7p22 lunatic fringe homolog (Drosophila) CARD11 7p22 caspase recruitment domain family, member 11 LOC392769 7 similar to hypothetical protein FLJ32949 C7orf27 7p22.3 chromosome 7 open reading frame 27 LOC392944 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PMPCB 7q21.3-q22.1 peptidase (mitochondrial processing) beta KIAA1023 7p22.3 KIAA1023 protein LOC392931 7 hypothetical gene supported by AL834121 LOC392770 7 similar to M-phase phosphoprotein 11 PSMC2 7q22.1-q22.3 proteasome (prosome, macropain) 26S subunit, ATPase, 2 MGC12518 7q11.21 similar to ZINC FINGER PROTEIN 257 (BONE MARROW ZINC FINGER 4) (BMZF-4) PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 PRES 7q22.1 prestin (motor protein) TTYH3 7p22 tweety homolog 3 (Drosophila) LOC392701 7 LOC392701 KIAA1950 7p22.3 KIAA1950 protein ZNF117 7q11.2 zinc finger protein 117 (HPF9) H-plk 7q11.21 Krueppel-related zinc finger protein LOC285919 7p22.3 hypothetical LOC285919 RELN 7q22 reelin GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 LOC392621 7 LOC392621 LOC392740 7 hypothetical gene supported by AF290475; BC037783
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1403 - 361 - -
  • isoform b
  • 8 - 2384 - 379 - -
  • isoform a
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunethymus   highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Lfng (89.2pc)
    homolog to rattus Lfng (90.5pc)
    Homologene
    FAMILY
  • glycosyltransferase 31 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • a soluble form may be derived from the membrane form by proteolytic processing
  • basic FUNCTION
  • essential mediator of somite segmentation and patterning
  • putative regulator of developmental processes through alternative regulation of the sensitivity of NOTCH receptor genes for their specific ligands (delta, Jagged 2)
  • glycosyl transferase with N-acetylglucosaminyltransferase activity with elongation of 0-linked fucose residues, on side chains located at some of the EGF-repeats of NOTCH
  • decreasing the binding of jagged 1 to Notch2 but not that of DELTA1
  • inhibiting Notch1 signaling in the presomitic mesoderm (Dunwoodie 2009)
  • involved in the regulation of T lymphopoiesis (Visan 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    Notch signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDO3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS