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FLASH GENE
Symbol LFNG contributors: SGE/npt - updated : 16-10-2009
HGNC name LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
HGNC id 6560
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
Lymphoid/Immunethymus   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Lfng (89.2pc)
homolog to rattus Lfng (90.5pc)
Homologene
FAMILY
  • glycosyltransferase 31 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • a soluble form may be derived from the membrane form by proteolytic processing
  • basic FUNCTION
  • essential mediator of somite segmentation and patterning
  • putative regulator of developmental processes through alternative regulation of the sensitivity of NOTCH receptor genes for their specific ligands (delta, Jagged 2)
  • glycosyl transferase with N-acetylglucosaminyltransferase activity with elongation of 0-linked fucose residues, on side chains located at some of the EGF-repeats of NOTCH
  • decreasing the binding of jagged 1 to Notch2 but not that of DELTA1
  • inhibiting Notch1 signaling in the presomitic mesoderm (Dunwoodie 2009)
  • involved in the regulation of T lymphopoiesis (Visan 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    Notch signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDO3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS