basic FUNCTION
| essential mediator of somite segmentation and patterning |
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putative regulator of developmental processes through alternative regulation of the sensitivity of NOTCH receptor genes for their specific ligands (delta, Jagged 2) |
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glycosyl transferase with N-acetylglucosaminyltransferase activity with elongation of 0-linked fucose residues, on side chains located at some of the EGF-repeats of NOTCH |
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decreasing the binding of jagged 1 to Notch2 but not that of DELTA1 |
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inhibiting Notch1 signaling in the presomitic mesoderm (Dunwoodie 2009) |
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involved in the regulation of T lymphopoiesis (Visan 2006) |