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FLASH GENE
Symbol LEAP2 contributors: mct - updated : 12-11-2021
HGNC name liver enriched antimicrobial peptide 2
HGNC id 29571
Location 5q31.1      Physical location : 132.209.357 - 132.210.581
Synonym name
  • liver-expressed antimicrobial peptide 2
    • Synonym symbol(s) LEAP-2
    DNA
    TYPE functioning gene
    STRUCTURE 1.38 kb     3 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 861 - 77 - 2020 32803260
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     liver   specific Homo sapiens
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 22 aa signal peptide
    • isoforms Precursor potential mature peptide of 55 aa
    HOMOLOGY
    interspecies homolog to murine leap2 (85.5 pc)
    Homologene
    FAMILY
  • LEAP2 family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having an antimicrobial activity
  • involved in defense response to bacterium
  • plasma LEAP2/acyl-ghrelin molar ratio may likely be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LEAP2 fully inhibits GHSR activation by ghrelin and blocks the major effects of ghrelin, including food intake, GH release, and maintenance of viable glucose levels during chronic caloric restriction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LEAP2 may have potential as a biomarker for bacterial meningitis
    • Therapy target
    ANIMAL & CELL MODELS
  • in female mice, LEAP2 deletion increases body length and exaggerates the hepatic fat accumulation normally associated with chronic high-fat diet feeding