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FLASH GENE
Symbol LEAP2 contributors: - updated : 13-11-2006
HGNC name liver expressed antimicrobial peptide 2
HGNC id 29571
Location 5q31.1      Physical location : 132.209.357 - 132.210.581
Synonym symbol(s) LEAP-2
DNA
TYPE functioning gene
STRUCTURE 1.23 kb     3 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 707 - 77 - Krause (2003)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 liver   specific
Endocrinepancreas    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 22 aa signal peptide
  • isoforms Precursor potential mature peptide of 55 aa
    HOMOLOGY
    interspecies homolog to murine leap2 (85.5 pc)
    Homologene
    FAMILY
  • LEAP2 family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having an antimicrobial activity
  • involved in defense response to bacterium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS