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FLASH GENE
Symbol LEAP2 contributors: mct - updated : 12-11-2021
HGNC name liver enriched antimicrobial peptide 2
HGNC id 29571
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 22 aa signal peptide
    • isoforms Precursor potential mature peptide of 55 aa
    HOMOLOGY
    interspecies homolog to murine leap2 (85.5 pc)
    Homologene
    FAMILY
  • LEAP2 family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having an antimicrobial activity
  • involved in defense response to bacterium
  • plasma LEAP2/acyl-ghrelin molar ratio may likely be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LEAP2 fully inhibits GHSR activation by ghrelin and blocks the major effects of ghrelin, including food intake, GH release, and maintenance of viable glucose levels during chronic caloric restriction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LEAP2 may have potential as a biomarker for bacterial meningitis
    • Therapy target
    ANIMAL & CELL MODELS
  • in female mice, LEAP2 deletion increases body length and exaggerates the hepatic fat accumulation normally associated with chronic high-fat diet feeding