| 1 | LDHA, POU1F1
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| POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation
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| Martínez-Ordoñez A, Seoane S, Avila L, Eiro N, Macía M, Arias E, Pereira F, García-Caballero T, Gómez-Lado N, Aguiar P, Vizoso F, Perez-Fernandez R.
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| Oncogene. Apr;40(15):2725-2740. doi: 10.1038/s41388-021-01740-6. Epub 2021 Mar 13. 2021
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| 2 | LDHA, PCK1
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| PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
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| Shi L, An S, Liu Y, Liu J, Wang F.
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| Onco Targets Ther 13:2613-2627. doi: 10.2147/OTT.S241717. eCollection 2020.
2020
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| 3 | LDHA
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| Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.
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| Sada N, Suto S, Suzuki M, Usui S, Inoue T.
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| Epilepsia pilepsia. 2020 Mar 23. doi: 10.1111/epi.16488. [Epub ahead of print]
2020
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| 4 | LDHA, MTA1, MYC
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| MTA1 coregulator regulates LDHA expression and function in breast cancer.
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| Guddeti RK, Bali P, Karyala P, Pakala SB.
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| Biochem Biophys Res Commun 520(1):54-59. doi: 10.1016/j.bbrc.2019.09.078. Epub 2019 Sep 27.
2019
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| 5 | LDHA, TP53
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| p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
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| Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M.
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| Cancer Sci 110(3):939-949. doi: 10.1111/cas.13928. Epub 2019 Jan 31.
2019
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| 6 | LDHA
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| LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma.
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| Hou XM, Yuan SQ, Zhao D, Liu XJ, Wu XA.
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| Biosci Rep 39(1). pii: BSR20181476. doi: 10.1042/BSR20181476. Print 2019 Jan 31.
2019
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| 7 | LDHA, LDHC
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| Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.
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| Dodo M, Kitamura H, Shima H, Saigusa D, Wati SM, Ota N, Katsuoka F, Chiba H, Okae H, Arima T, Igarashi K, Koseki T, Sekine H, Motohashi H.
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| J Biochem. Apr 1;165(4):323-334. doi: 10.1093/jb/mvy108 2019
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| 8 | LDHA, LDHB
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| Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells.
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| Urbańska K, Orzechowski A.
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| Int J Mol Sci. Apr 27;20(9):2085. doi: 10.3390/ijms20092085 2019
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| 9 | ATF4, LDHA
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| Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
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| Pathria G, Scott DA, Feng Y, Sang Lee J, Fujita Y, Zhang G, Sahu AD, Ruppin E, Herlyn M, Osterman AL, Ronai ZA.
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| EMBO J 37(20). pii: e99735. doi: 10.15252/embj.201899735. Epub 2018 Sep 12.
2018
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| 10 | LDHA
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| Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis.
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| Lin H, Muramatsu R, Maedera N, Tsunematsu H, Hamaguchi M, Koyama Y, Kuroda M, Ono K, Sawada M, Yamashita T.
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| EBioMedicine 27:71-85. doi: 10.1016/j.ebiom.2017.10.033. Epub 2017 Dec 7.
2018
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| 11 | KCNJ11, LDHA
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| NFκB mediated elevation of KCNJ11 promotes tumor progression of hepatocellular carcinoma through interaction of lactate dehydrogenase A.
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| Zhang K, Mu L, Ding MC, Xu R, Ding ZJ, Liang J.
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| Biochem Biophys Res Commun 495(1):246-253. doi: 10.1016/j.bbrc.2017.11.011. Epub 2017 Nov 3.
2018
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| 12 | LDHA
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| Lactate dehydrogenase-A is indispensable for vascular smooth muscle cell proliferation and migration.
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| Kim JH, Bae KH, Byun JK, Lee S, Kim JG, Lee IK, Jung GS, Lee YM, Park KG.
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| Biochem Biophys Res Commun 492(1):41-47. doi: 10.1016/j.bbrc.2017.08.041. Epub 2017 Aug 14.
2017
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| 13 | LDHA
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| Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
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| Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S.
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| Oncogene 36(27):3797-3806. doi: 10.1038/onc.2017.6. Epub 2017 Feb 20.
2017
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| 14 | LDHA
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| Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.
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| Manerba M, Di Ianni L, Govoni M, Roberti M, Recanatini M, Di Stefano G.
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| Eur J Pharm Sci 96:37-44. doi: 10.1016/j.ejps.2016.09.014. Epub 2016 Sep 10.
2017
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| 15 | LDHA, LDHB, NFATC1, TNFSF11
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| Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling.
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| Ahn H, Lee K, Kim JM, Kwon SH, Lee SH, Lee SY, Jeong D.
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| PLoS One 11(4):e0153886. doi: 10.1371/journal.pone.0153886. eCollection 2016.
2016
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| 16 | LDHA, PKM
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| M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.
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| Casson RJ, Wood JP, Han G, Kittipassorn T, Peet DJ, Chidlow G.
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| Invest Ophthalmol Vis Sci 57(1):66-80. doi: 10.1167/iovs.15-17962.
2016
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| 17 | FOXM1, LDHA
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| FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression.
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| Jiang W, Zhou F, Li N, Li Q, Wang L.
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| Int J Clin Exp Pathol 8(6):6756-63. eCollection 2015.
2015
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| 18 | LDHA
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| Inhibition of LDHA suppresses tumor progression in prostate cancer.
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| Xian ZY, Liu JM, Chen QK, Chen HZ, Ye CJ, Xue J, Yang HQ, Li JL, Liu XF, Kuang SJ.
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| Tumour Biol 36(10):8093-100. doi: 10.1007/s13277-015-3540-x. Epub 2015 May 16.
2015
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| 19 | LDHA
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| Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
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| Kolappan S, Shen DL, Mosi R, Sun J, McEachern EJ, Vocadlo DJ, Craig L.
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| Acta Crystallogr D Biol Crystallogr 71(Pt 2):185-95. doi: 10.1107/S1399004714024791. Epub 2015 Jan 23.
2015
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| 20 | LDHA
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| Lactate dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma.
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| Girgis H, Masui O, White NM, Scorilas A, Rotondo F, Seivwright A, Gabril M, Filter ER, Girgis AH, Bjarnason GA, Jewett MA, Evans A, Al-Haddad S, Siu KM, Yousef GM.
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| Mol Cancer 13:101. doi: 10.1186/1476-4598-13-101.
2014
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| 21 | LDHA
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| Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium.
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| Parra-Bonilla G, Alvarez DF, Alexeyev M, Vasauskas A, Stevens T.
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| PLoS One 8(9):e75984. doi: 10.1371/journal.pone.0075984. eCollection 2013.
2013
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| 22 | LDHA, LDHC
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| Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.
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| Tang H, Duan C, Bleher R, Goldberg E.
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| Biol Reprod 88(4):96. doi: 10.1095/biolreprod.112.107011. Print 2013 Apr.
2013
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| 23 | LDHA
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| Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma.
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| Sheng SL, Liu JJ, Dai YH, Sun XG, Xiong XP, Huang G.
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| FEBS J 279(20):3898-910. doi: 10.1111/j.1742-4658.2012.08748.x. Epub 2012 Sep 13.
2012
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| 24 | LDHA
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| Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
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| Fan J, Hitosugi T, Chung TW, Xie J, Ge Q, Gu TL, Polakiewicz RD, Chen GZ, Boggon TJ, Lonial S, Khuri FR, Kang S, Chen J.
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| Mol Cell Biol 31(24):4938-50. doi: 10.1128/MCB.06120-11. Epub 2011 Oct 3.
2011
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| 25 | LDHA, LDHB
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| High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
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| Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L.
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| Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. doi: 10.1073/pnas.1008189107. Epub 2010 Nov 1. 2010
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| 26 | ERBB2, LDHA
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| Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.
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| Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M.
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| Oncogene 28(42):3689-701. doi: 10.1038/onc.2009.229. Epub 2009 Aug 10.
2009
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| 27 | LDHA
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| Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
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| Fantin VR, St-Pierre J, Leder P.
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| Cancer Cell 9(6):425-34. Erratum in: Cancer Cell. 2006 Aug;10(2):172.
2006
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| 28 | LDHA
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| Identification of mono-ubiquitinated LDH-A in skeletal muscle cells exposed to oxidative stress.
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| Onishi Y, Hirasaka K, Ishihara I, Oarada M, Goto J, Ogawa T, Suzue N, Nakano S, Furochi H, Ishidoh K, Kishi K, Nikawa T.
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| Biochem Biophys Res Commun 336(3):799-806. 2005
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| 29 | LDHA
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| Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.
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| Li X, Qin C, Burghardt R, Safe S.
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| Biochem Biophys Res Commun 320(3):625-34. 2004
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| 30 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
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| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
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| Dang CV.
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| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
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| 31 | LDHA, LDHAD
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| A novel deletion mutation of lactate dehydrogenase A(M) gene in the fifth family with the enzyme deficiency.
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| Maekawa M, et al.
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| Hum Mol Genet 3 : 825-826. 1994
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| 32 | LDHA
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| Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.
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| Sudo K, et al.
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| Biochem Int 27 : 1051-1058. 1992
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| 33 | LDHA
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| Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining.
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| Maekawa M, et al.
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| Biochem Biophys Res Commun 180 : 1083-1090. 1991
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| 34 | LDHA, LDHAD
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| Genotypic analysis of families with lactate dehydrogenase A(M) deficiency by selective DNA amplification.
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| Maekawa M, et al.
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| Hum Genet 88 : 34-38. 1991
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| 35 | LDHA
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| Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.
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| Maekawa M, et al.
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| Biochem Biophys Res Commun 168 : 677-682. 1990
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| 36 | LDHA, LDHAD
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| Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.
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| Maekawa M, Sudo K, Kanno T, Li SS.
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| Biochem Biophys Res Commun 168(2):677-82.
1990
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| 37 | LDHA
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| Lactate dehydrogenase M-subunit deficiency : a new type of hereditary exertional myopathy.
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| Kanno T, et al.
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| Clin Chim Acta 173 : 89-98. 1988
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| 38 | LDHA, LDHB, LDHC, LDHAL1, LDHAL2, LDHAL3, LDHAL4, LDHAL5, LDHBL1, LDHBP
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| Mapping of human lactate dehydrogenase-A, -B, and -C genes and their related sequences : the gene for LDHC is located with that for LDHA on chromosome 11.
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| Li SSL, et al.
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| Cytogenet Cell Genet 48 : 16-18. 1988
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| 39 | LDHA
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| The gene coding for lactate dehydrogenase A is located between catalase and the beta-globin gene complex.
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| Gerhard DS, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 619. 1987
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| 40 | LDHA
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| Localization of the LDHA gene to 11p14->11p15 by in situ hybridization of an LDHA cDNA probe to two translocations with breakpoints in 11p13.
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| Yang-Feng TL, et al.
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| Hum Genet 74 : 331-334. 1986
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| 41 | HB-NA@, PTH, INS, LDHA
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| Mapping parathyroid hormone, beta-globin, insulin, and LDH-A genes within the human chromosome 11 short arm by spot blotting sorted chromosomes.
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| Lebo RV, et al.
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| Hum Genet 69 : 316-320. 1985
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| 42 | LDHA
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| Gene order on the short arm of human chromosome 11 : regional assignment of the LDHA gene distal to catalase in two translocations.
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| Lewis WH, et al.
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| Hum Genet 71 : 249-253. 1985
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| 43 | LDHA, LDHAD
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| Hereditary deficiency of lactate dehydrogenase M-subunit.
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| Kanno T, et al.
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| Clin Chim Acta 108 : 267-276. 1980
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| 44 | LDHA
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| Gene dose effect: intraband mapping of the LDHA locus using cells from four individuals with different interstitial deletions of 11p.
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| Francke U, et al.
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| Cytogenet Cell Genet 19 : 197-207. 1977
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| 45 | LDHA, TK1
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| Assignment of three human genes to chromosomes (LDH-A to 11, TK to 17, and IDH to 20) and evidence for translocation between human and mouse chromosomes in somatic cell hybrids.
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| Boone C, et al.
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| Proc Natl Acad Sci U S A 69 : 510-514. 1972
|