basic FUNCTION
| involved in the transport of hydrophobic ligands (retinol transport)and of small lipophilic substances |
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modulator of inflammation (prostaglandin synthesis) |
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immune system homeostasis |
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suppressing growth induced by IL3, but not influencing CSF3-dependent cell growth |
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iron-siderophore-binding protein, converting embryonic kidney mesenchyme to epithelia |
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epithelial inducer in Ras malignancy and suppressor of metastasis |
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iron transporter with functions distinct from that of transferrin and mediating a new iron-delivery pathway ![](pubmed.jpg) |
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lineage-specific role in hematopoiesis, having important function in the regulation of hematopoiesis ![](pubmed.jpg) |
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adipokine that potentially connects obesity and its related adipose inflammation ![](pubmed.jpg) |
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autocrine and paracrine adipokine, acts as an antagonist to the effect of inflammatory molecules on inflammation and secretion of adipokines ![](pubmed.jpg) |
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potential suppressor of invasion and angiogenesis in advanced pancreatic cancer ![](pubmed.jpg) |
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important biomarker in clinical nephrology, extending to chronic kidney disease the pathophysiological role of this protein in tubular adaptations to renal damage ![](pubmed.jpg) |
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plays a role as an iron-sequestering protein in the antibacterial innate immune response |
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induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore ![](pubmed.jpg) |
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may actively participate in breast cancer progression ![](pubmed.jpg) |
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siderophore-binding antimicrobial protein, critical for control of systemic infection with Escherichia coli ![](pubmed.jpg) |
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being a crucial component of mucosal immune defense against pulmonary infection with K. pneumoniae ![](pubmed.jpg) |
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critical selective modulator of PPARG activation and function in lipid homeostasis and energy expenditure 8) |
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SLC22A17, in cooperation with LCN2, is involved in the acquisition of aggressive behavior among endometrial carcinoma cells ![](pubmed.jpg) |
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controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation ![](pubmed.jpg) |
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promotes cell migration through up-regulation of chemokines in brain ![](pubmed.jpg) |
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essential role for LCN2 as a protein required for the reactive astrocytosis and cell migration in the CNS ![](pubmed.jpg) |
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LCN2 accelerated neuronal motility and process extension, suggesting multiple roles for LCN2 in the regulation of neuronal cell death, migration, and morphology ![](pubmed.jpg) |
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LCN2-induced cardiomyocyte apoptosis is of physiological significance and occurs via a mechanism involving elevated intracellular iron levels and BAX translocation ![](pubmed.jpg) |
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is a molecular actor in neuroinflammation in early clinical stages of Alzheimer disease ![](pubmed.jpg) |
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novel role as an important paracrine chemoattractant and an indispensable factor for neutrophil function in inflammation ![](pubmed.jpg) |
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promotes angiogenesis, suggesting a novel mechanism through which LCN2 may promote tumor progression ![](pubmed.jpg) |
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STEAP4 and LCN2 mRNA and protein levels in visceral adipose tissue are related to iron status![](pubmed.jpg) |
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is an M1-amplifier in brain microglial cells ![](pubmed.jpg) |