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FLASH GENE
Symbol LARS contributors: mct/npt/pgu - updated : 29-04-2013
HGNC name leucyl-tRNA synthetase
HGNC id 6512
Location 5q32      Physical location : 145.492.588 - 145.562.294
Synonym name
  • leucine tRNA ligase 1, cytoplasmic
  • proliferation-inducing gene 44
  • cytosolic leucyl-tRNA synthetase
  • Synonym symbol(s) LEUS, LARS1, RNTLS, HSPC192, FLJ10595, FLJ21788, KIAA1352, LEURS, LRS, PIG44, hr025Cl
    EC.number 6.1.1.4
    DNA
    TYPE functioning gene
    STRUCTURE 69.71 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Physical map
    SMAP-5 5q32 golgi membrane protein SB140 KIAA1317 5q32 KIAA1317 protein ASSP10 5q13-q23 argininosuccinate synthetase pseudogene 10 LOC391837 5 similar to transient receptor potential cation channel, subfamily C, member 6; transient receptor potential channel 6 MGC21644 5q32 hypothetical protein MGC21644 FLJ23654 5q32 hypothetical protein FLJ23654 LOC153770 5q32 similar to protein related with psoriasis LARS 5q32 leucyl-tRNA synthetase KIAA1311 5q32 KIAA1311 protein POU4F3 5q31-q32 POU domain, class 4, transcription factor 3 TCERG1 5q31 transcription elongation regulator 1 (CA150) GPR151 5q32 G protein-coupled receptor 151 PPP2R2B 5q31-q33 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform MGC22688 5q32 hypothetical protein MGC22688 DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4868 134.3 1176 - 2007 17363246
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  highly
    Reproductivefemale systembreastmammary gland highly
     male systemprostate   
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal extension is indispensable for its interaction with the N-terminal of cytosolic arginyl-tRNA synthetase in the macromolecular complex
  • HOMOLOGY
    Homologene
    FAMILY
  • class-1 aminoacyl-tRNA synthetase family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text localizes predominantly to the cytosol
    basic FUNCTION
  • may play roles in migration and growth of lung cancer cells, which suggest its potential implication in lung tumorigenesis
  • plays a critical role in amino acid-induced MTOR activation by sensing intracellular leucine concentration and initiating molecular events leading to MTOR activation
  • enzyme responsible for exclusively attaching leucine to its cognate tRNA during protein translation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential interaction network may exist between LARS and EF-1 subunits probably to enhance the efficiency of protein synthesis
  • is a key mediator for amino acid signaling to MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary lung cancer tissues
    constitutional germinal mutation      
    G3283A transition in the mitochondrial DNA tRNA(Leu (UUR)) gene in a patient with ptosis, ophthalmoparesis and hyporeflexia
    constitutional germinal mutation      
    in infantile hepatopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS