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FLASH GENE
Symbol LARS contributors: mct/npt/pgu - updated : 29-04-2013
HGNC name leucyl-tRNA synthetase
HGNC id 6512
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestivemouth   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal extension is indispensable for its interaction with the N-terminal of cytosolic arginyl-tRNA synthetase in the macromolecular complex
  • HOMOLOGY
    Homologene
    FAMILY
  • class-1 aminoacyl-tRNA synthetase family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text localizes predominantly to the cytosol
    basic FUNCTION
  • may play roles in migration and growth of lung cancer cells, which suggest its potential implication in lung tumorigenesis
  • plays a critical role in amino acid-induced MTOR activation by sensing intracellular leucine concentration and initiating molecular events leading to MTOR activation
  • enzyme responsible for exclusively attaching leucine to its cognate tRNA during protein translation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential interaction network may exist between LARS and EF-1 subunits probably to enhance the efficiency of protein synthesis
  • is a key mediator for amino acid signaling to MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary lung cancer tissues
    constitutional germinal mutation      
    G3283A transition in the mitochondrial DNA tRNA(Leu (UUR)) gene in a patient with ptosis, ophthalmoparesis and hyporeflexia
    constitutional germinal mutation      
    in infantile hepatopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS