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FLASH GENE
Symbol KRT86 contributors: mct/npt - updated : 30/10/2008
HGNC name keratin 86
HGNC id 6463
Corresponding disease
MNX monilethrix
Location 12q13      Physical location : 52.695.648 - 52.702.945
Synonym name
  • hair keratin, type II
  • keratin, hair, basic, 6 (monilethrix)
  • keratin type II cuticular Hb6
    • Synonym symbol(s) HB6, KRTHB6, Hb1, KRTHB1, MNX, K86, K2.11
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 7.30 kb     9 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    regionally located clustered with other basic keratins in a domain flanked by type II epithelial keratins, subcluster 1 (with KRTHB1, KRTHB3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2091 53.5 486 - Schweizer (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Respiratorylung   highly
    Skin/Tegumentskin appendageshairfollicle  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text differentiating hair cortical cells during anagen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cysteine-rich domain
  • a central rod domain composed of 4 alpha helical coiled coils repeats separated by linker region
  • a C terminal globular region
    • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • having structural molecule activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRTHA1
  • heterodimerizes with type I keratins to form hair and nails
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MNX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS