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FLASH GENE
Symbol KRT86 contributors: mct/npt - updated : 30/10/2008
HGNC name keratin 86
HGNC id 6463
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Respiratorylung   highly
Skin/Tegumentskin appendageshairfollicle  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text differentiating hair cortical cells during anagen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cysteine-rich domain
  • a central rod domain composed of 4 alpha helical coiled coils repeats separated by linker region
  • a C terminal globular region
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • having structural molecule activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRTHA1
  • heterodimerizes with type I keratins to form hair and nails
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MNX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS