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FLASH GENE
Symbol KRT85 contributors: mct/npt - updated : 30/10/2008
HGNC name keratin 85
HGNC id 6462
Corresponding disease
EDHN1 ectodermal dysplasia, 'pure' hair-nail type 1
Location 12q13      Physical location : 52.753.791 - 52.761.309
Synonym name
  • hard keratin, type II
  • keratin, hair, basic, 5
  • keratin type II cuticular Hb5
    • Synonym symbol(s) HB5, KRTHB5, Hb-5, K85, K12.12
    DNA
    TYPE functioning gene
    STRUCTURE 7.52 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located clustered with other basic keratins in a domain flanked by type II epithelial keratins, subcluster 2 (with KRT82, KRT84)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2491 55.79 507 - Schweizer (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunethymus    
    Reproductivemale systemtestis   
    Skin/Tegumentskin appendageshairfollicle  
     skin appendageshairsheath  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • N terminal cysteine-rich domain
  • a central rod domain composed of four alpha helical coiled- coil repeats separated by linker region
  • a C terminal globular region
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • basic protein which heterodimerizes with type I keratins to form hair and nails
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with type I keratins
  • heterotetramer of two type I and two type II keratins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDHN1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS