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FLASH GENE
Symbol KRT85 contributors: mct/npt - updated : 30/10/2008
HGNC name keratin 85
HGNC id 6462
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • N terminal cysteine-rich domain
  • a central rod domain composed of four alpha helical coiled- coil repeats separated by linker region
  • a C terminal globular region
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • basic protein which heterodimerizes with type I keratins to form hair and nails
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with type I keratins
  • heterotetramer of two type I and two type II keratins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDHN1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS