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FLASH GENE
Symbol KRT16 contributors: mct/npt - updated : 24/09/2008
HGNC name keratin 16
HGNC id 6423
Corresponding disease
NEPPK palmoplantar keratoderma (hyperkeratosis), nonepidermolytic
PC117 pachyonychia congenita, type 1
Location 17q21-q22      Physical location : 39.766.032 - 39.769.079
Synonym name
  • cytokeratin 16
  • keratin, type I cytoskeletal 16
  • focal non-epidermolytic palmoplantar keratoderma
  • Synonym symbol(s) CYK16, K16, CK16, K1CP, NEPPK, KRT16A
    DNA
    TYPE functioning gene
    STRUCTURE 2.99 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    KRTAP9P1 17q12-q21 keratin associated protein 9 pseudogene 1 LOC390794 17 similar to keratin associated protein 4-12; keratin associated protein 4.12 KRTAP16-1 17q12-q21 keratin associated protein 16-1 KRTAP17-1 17q12-q21 keratin associated protein 17-1 KRTHA3A 17q12-q21 keratin, hair, acidic, 3A KRTHA3B 17q12-q21 keratin, hair, acidic, 3B KRTHA4 17q12-q21 keratin, hair, acidic, 4 KRTHA1 17q12-q21 keratin, hair, acidic, 1 KRTHAP1 17q12-q21 keratin, hair, acidic, pseudogene 1 KRTHA7 17q12-q21 keratin, hair, acidic, 7 KRTHA8 17q12-q21 keratin, hair, acidic, 8 KRTHA2 17q12-q21 keratin, hair, acidic, 2 KRTHA5 17q12-q21 keratin, hair, acidic, 5 KRTHA6 17q12-q21 keratin, hair, acidic, 6 KRT13 17q21-q22 keratin 13 KRT15 17q21.2 keratin 15 KRT19 17q21 keratin 19 KRT9 17q21.1-q21.2 keratin 9 (epidermolytic palmoplantar keratoderma) KRT14 17q21-q22 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) KRT16 17q21-q22 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) KRT17 17q21-q22 keratin 17 LOC388385 17 LOC388385 SUI1 17q21.31 putative translation initiation factor GAS 17q21-q21.2 gastrin HAP1 17q21.2-q21.3 huntingtin-associated protein 1 (neuroan 1) JUP 17q21 junction plakoglobin SC65 17q21.31 synaptonemal complex protein SC65 FKBP10 17q21.1 FK506 binding protein 10, 65 kDa MGC20781 17q21.31 hypothetical protein MGC20781 KLHL10 17q21.2 kelch-like 10 (Drosophila) FLJ10572 17q21.31 hypothetical protein FLJ10572 ACLY 17q21-q22 ATP citrate lyase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1720 51.3 473 - Ito (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouthtongue   
     pharynx   highly
    Respiratoryrespiratory tractlarynx  highly
    skin tegumentpalmoplantar    
    Skin/Tegumentskin appendageshairfollicle  
     skin appendagesnails   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved central rod domain
  • made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3) and flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Krt1-16
    homolog to C.elegans F37C12.12
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text coexpressed with keratin 14
    basic FUNCTION
  • responsible for the structural integrity of epithelial cells
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • cell shape and cell size control
  • epidermal differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT6A, KRT6B
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
  • associating with KRT6 isomers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KRT6 isomers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC117 , NEPPK
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS