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FLASH GENE
Symbol KRT16 contributors: mct/npt - updated : 08-06-2018
HGNC name keratin 16
HGNC id 6423
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouthtongue   
 pharynx   highly
Respiratoryrespiratory tractlarynx  highly
skin tegumentpalmoplantar    
Skin/Tegumentskin appendageshairfollicle  
 skin appendagesnails   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain
  • made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3) and flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Krt1-16
    homolog to C.elegans F37C12.12
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text coexpressed with keratin 14
    basic FUNCTION
  • responsible for the structural integrity of epithelial cells
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • cell shape and cell size control
  • epidermal differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT6A, KRT6B
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
  • associating with KRT6 isomers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KRT6 isomers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC117 , NEPPK
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS