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FLASH GENE
Symbol KNSTRN contributors: mct - updated : 25-04-2015
HGNC name kinetochore localized astrin (SPAG5) binding protein
HGNC id 30767
Location 15q15.1      Physical location : -
Genatlas name small kinetochore associated protein
Synonym name
  • TRAF4 associated factor 1
  • kinastrin
  • chromosome 15 open reading frame 23
  • Synonym symbol(s) FLJ14502, TRAF4AF1, HSD11, MGC141729, MGC141728, C15orf23, SKAP
    DNA
    TYPE functioning gene
    STRUCTURE 11.57 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1763 35 316 - 2009 19667759
    9 - 2039 - 286 - 2009 19667759
    8 - 1701 - 241 - 2009 19667759
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region of KNSTRN associates with spindle microtubules, although it is not sufficient to localize to the kinetochore
  • C-terminal region of KNSTRN is responsible for its kinetochore localization
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to spindle MTs and kinetochores in mitosis
  • localizes at the outer kinetochore and is essential for chromosome alignment
  • basic FUNCTION
  • G(2)-induced gene and regulator for the anaphase onset
  • kinetochore and mitotic spindle protein
  • constituent of the kinetochore corona fibers of mammalian centromere
  • cooperates with CENPE to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation
  • is essential for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis
  • constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
  • GSK3B-SKAP-KIF2B signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division
  • likely SPAG5-SKAP complex acts together with the NDC80 complex to stabilize correctly formed kinetochore-microtubule interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • major SPAG5-interacting protein in mitotic cells, and is required for astrin targeting to microtubule plus ends proximal to the plus tip tracking protein EB1
  • interaction between CENPE and SKAP that functions synergistically in governing dynamic kinetochore-microtubule interactions
  • KNSTRN physically interacts with DSN1 and specifies kinetochore localization of KNSTRN
  • cell & other
  • targeting of the SPAG5-SKAP complex to bioriented kinetochores, controled by AURKB
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS