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FLASH GENE
Symbol KNSTRN contributors: mct - updated : 25-04-2015
HGNC name kinetochore localized astrin (SPAG5) binding protein
HGNC id 30767
DNA
TYPE functioning gene
STRUCTURE 11.57 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1763 35 316 - 2009 19667759
9 - 2039 - 286 - 2009 19667759
8 - 1701 - 241 - 2009 19667759
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region of KNSTRN associates with spindle microtubules, although it is not sufficient to localize to the kinetochore
  • C-terminal region of KNSTRN is responsible for its kinetochore localization
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to spindle MTs and kinetochores in mitosis
  • localizes at the outer kinetochore and is essential for chromosome alignment
    • basic FUNCTION
  • G(2)-induced gene and regulator for the anaphase onset
  • kinetochore and mitotic spindle protein
  • constituent of the kinetochore corona fibers of mammalian centromere
  • cooperates with CENPE to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation
  • is essential for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis
  • constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
  • GSK3B-SKAP-KIF2B signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division
  • likely SPAG5-SKAP complex acts together with the NDC80 complex to stabilize correctly formed kinetochore-microtubule interactions
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • major SPAG5-interacting protein in mitotic cells, and is required for astrin targeting to microtubule plus ends proximal to the plus tip tracking protein EB1
  • interaction between CENPE and SKAP that functions synergistically in governing dynamic kinetochore-microtubule interactions
  • KNSTRN physically interacts with DSN1 and specifies kinetochore localization of KNSTRN
    • cell & other
  • targeting of the SPAG5-SKAP complex to bioriented kinetochores, controled by AURKB
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS