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FLASH GENE
Symbol KLLN contributors: mct - updated : 03-12-2015
HGNC name killin, p53-regulated DNA replication inhibitor
HGNC id 37212
Corresponding disease
CWS4 Cowden syndrome 4
Location 10q23.31      Physical location : -
Synonym symbol(s) CWS4, KILLIN
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text is transcribed in the opposite direction of PTEN
STRUCTURE 4.28 kb     1 Exon(s)
regulatory sequence Promoter
text structure
  • shares a bidirectional promoter with PTEN
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4277 - 178 - 2008 18385383
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is not only necessary but also sufficient for TP53-induced apoptosis
  • tumor suppressor in breast carcinomas, which inhibits tumor growth and invasiveness
  • transcription factor that regulates the cell cycle and induces apoptosis in cancer cells
  • is an androgen-regulated gene
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CWS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    germline and somatic KLLN mutations in breast cancer dysregulate G2 arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLLN expression may be used in prostate carcinoma as a prognostic marker to predict outcome for intermediate risk patients, which could provide useful information for postoperative management
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    might be used as a potential prognostic marker and novel therapy target for breast carcinomas
    ANIMAL & CELL MODELS