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FLASH GENE
Symbol KLK8 contributors: mct - updated : 10-01-2011
HGNC name kallikrein-related peptidase 8
HGNC id 6369
Location 19q13.41      Physical location : 51.499.263 - 51.504.958
Synonym name
  • ovasin-potential marker for ovarian carcinoma
  • neuropsin
  • kallikrein 8 (neuropsin/ovasin)
  • tumor-associated differentially expressed gene 14 protein
  • serine protease TADG-14
  • Synonym symbol(s) PRSS19, TADG14, HNP, NRPN, NP
    EC.number 3.4.21.118
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 5.70 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7 LOC284367 19q13.41 hypothetical protein LOC284367 SIGLECP1 19q13.33 sialic acid binding Ig-like lectin, pseudogene 1 CD33 19q13.3 CD33 antigen (gp67)
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1013 - 260 brain 2007 17487847
    neuropsin type 1
    6 initiation site 1148 - 305 hippocampus, fetal brain, placenta; abundantly expressed in embryonic stem cells and in embryo brain samples, suggesting a potential role in embryogenesis 2007 17487847
  • neuropsin type 2
  • insert of 45 AA at the N terminus of leader sequence
  • important role in the normal function of the cognition
  • only in the humans
  • 4 - 590 - 119 - 2007 17487847
    3 - 456 - 32 - 2007 17487847
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
     salivary gland     Homo sapiens
    Lymphoid/Immunetonsils     Homo sapiens
    Nervousbraindiencephalonamygdala highly Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systembreast  highly Homo sapiens
    Skin/Tegumentskin appendagesskin glandsweat gland highly Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum corneum  Homo sapiens
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion breast milk, amniotic fluid, seminal fluid and serum
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a trypsin-like activity
  • involved in the pathogenesis of inflammatory skin diseases
  • involved in desquamation cascade of the skin
  • involved in proliferation of keratinocytes and desquamation possibly through other kallikreins
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor
  • might be involved in desquamation through the degradation of adhesive molecules that connect layers of the epidermis and in tissue development and rearrangement
  • keratinocyte-specific protease, having an active role for in upper epidermis
  • active serine protease in stratum corneum and sweat, with potential regulators and targets that augment its involvement in a skin barrier proteolytic cascade
  • key regulator of the FKBP5 gene and protein expression
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS development
    text both types necessary for brain development type 2, also important in brain plasticity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves the extracellular portion of EPHB2 and facilitates the dynamic interaction of EPHB2 with the NR1 subunit of the NMDA receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in skin diseases, such as psoriasis vulgaris, lichen planus, and atopic dermatitis
    tumoral     --over  
    confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness
    tumoral     --over  
    in oral squamous cell carcinoma and may be implicated in malignant progression
    tumoral     --over  
    in most salivary gland tumors
    constitutional     --over  
    in skin inflammation increased expression in the stratum spinosum
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLK8-T4 alternative splice variant, alone or in combination, may be a new independent marker of unfavorable prognosis in lung cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • on stress, neuropsin-deficient mice do not show EphB2 cleavage and its dissociation from NR1 resulting in a static EphB2–NR1 interaction, attenuated induction of the Fkbp5 gene and low anxiety