| 1 | KLK8
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| Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.
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| Münster Y, Keyvani K, Herring A.
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| Exp Neurol 324:113115. doi: 10.1016/j.expneurol.2019.113115. Epub 2019 Nov 14.
2020
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| 2 | KLK8
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| CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer's disease.
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| Teuber-Hanselmann S, Rekowski J, Vogelgsang J, von Arnim C, Reetz K, Stang A, Jöckel KH, Wiltfang J, Esselmann H, Otto M, Tumani H, Herring A, Keyvani K.
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| J Neurol Neurosurg Psychiatry 91(1):40-48. doi: 10.1136/jnnp-2019-321073. Epub 2019 Aug 1.
2020
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| 3 | KLK14, KLK8, KLK9
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| LEKTI domains D6, D7 and D8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome.
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| Wiegmann H, Valentin F, Tarinski T, Liebau E, Loser K, Traupe H, Oji V.
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| Br J Dermatol 181(5):999-1008. doi: 10.1111/bjd.17820. Epub 2019 Jun 6.
2019
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| 4 | KLK10, KLK15, KLK2, KLK3, KLK6, KLK7, KLK8
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| Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
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| Tailor PD, Kodeboyina SK, Bai S, Patel N, Sharma S, Ratnani A, Copland JA, She JX, Sharma A.
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| Oncotarget 9(25):17876-17888. doi: 10.18632/oncotarget.24947. eCollection 2018 Apr 3.
2018
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| 5 | CCL14, KLK5, KLK8
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| Kallikrein-related peptidases are activators of the CC chemokine CCL14.
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| Grünberg M, Quandt D, Cynis H, Demuth HU, Kindermann A, Magdolen V, Forssmann WG, Seliger B, Mägert HJ.
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| Eur J Immunol 48(9):1592-1594. doi: 10.1002/eji.201747452. Epub 2018 Aug 22.
2018
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| 6 | KLK8
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| Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
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| Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P.
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| Sci Rep 8(1):10705. doi: 10.1038/s41598-018-29058-6.
2018
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| 7 | KLK8
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| A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.
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| Konar A, Kumar A, Maloney B, Lahiri DK, Thakur MK.
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| Sci Rep 8(1):9928. doi: 10.1038/s41598-018-27640-6.
2018
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| 8 | KLK8
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| Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease.
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| Keyvani K, Münster Y, Kurapati NK, Rubach S, Schönborn A, Kocakavuk E, Karout M, Hammesfahr P, Wang YC, Hermann DM, Teuber-Hanselmann S, Herring A.
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| Brain Pathol 28(6):947-964. doi: 10.1111/bpa.12599. Epub 2018 Apr 10.
2018
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| 9 | KLK5, KLK6, KLK7, KLK8, KLK9
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| Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
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| Adamopoulos PG, Kontos CK, Scorilas A.
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| Sci Rep 7(1):17299. doi: 10.1038/s41598-017-16269-6.
2017
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| 10 | KLK8
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| Elevated expression of KLK8 predicts poor prognosis in colorectal cancer.
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| Liu X, Quan B, Tian Z, Xi H, Jia G, Wang H, Zhang L, Liu R, Ma C, Han F, Li H, Yuan F.
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| Biomed Pharmacother 88:595-602. doi: 10.1016/j.biopha.2017.01.112. Epub 2017 Jan 28.
2017
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| 11 | KLK8
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| Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
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| Cao B, Yu Q, Zhao W, Tang Z, Cong B, Du J, Lu J, Zhu X, Ni X.
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| Sci Rep 7:20024. doi: 10.1038/srep20024. Erratum in: Sci Rep. 2016 Apr 29;6:25038. Cong, Binghai [corrected to Cong, Binhai].
2016
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| 12 | KLK8
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| Clinical relevance of the deregulated kallikrein-related peptidase 8 mRNA expression in breast cancer: a novel independent indicator of disease-free survival.
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| Michaelidou K, Ardavanis A, Scorilas A.
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| Breast Cancer Res Treat 152(2):323-36. doi: 10.1007/s10549-015-3470-8. Epub 2015 Jun 24.
2015
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| 13 | KLK6, KLK8
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| Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
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| Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S.
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| J Invest Dermatol 132(6):1717-24. doi: 10.1038/jid.2012.18. Epub 2012 Feb 23.
2012
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| 14 | KLK8
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| Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic Cascade.
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| Eissa A, Amodeo V, Smith CR, Diamandis EP.
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| J Biol Chem 286(1):687-706. Epub 2010 Oct 12.PMID: 20940292 2011
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| 15 | EPHB2, KLK8
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| Neuropsin cleaves EphB2 in the amygdala to control anxiety.
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| Attwood BK, Bourgognon JM, Patel S, Mucha M, Schiavon E, Skrzypiec AE, Young KW, Shiosaka S, Korostynski M, Piechota M, Przewlocki R, Pawlak R.
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| Nature 473(7347):372-5. Epub 2011 Apr 20.
2011
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| 16 | KLK8
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| Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.
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| Ishikawa Y, Tamura H, Shiosaka S.
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| J Physiol 589(Pt 14):3559-73. doi: 10.1113/jphysiol.2011.206169. Epub 2011 Jun 6.
2011
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| 17 | KLK8
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| Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer.
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| Planque C, Choi YH, Guyetant S, Heuzé-Vourc'h N, Briollais L, Courty Y.
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| Clin Chem 56(6):987-97. Epub 2010 Apr 1.PMID: 20360129 2010
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| 18 | KLK8
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| Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin.
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| Shingaki K, Matsuzaki S, Taniguchi M, Kubo T, Fujiwara T, Kanazawa S, Yamamoto A, Tamura H, Maeda T, Ooi K, Matsumoto K, Shiosaka S, Tohyama M.
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| Br J Dermatol 163(3):466-75. doi: 10.1111/j.1365-2133.2010.09864.x. Epub 2010 Aug 12.PMID: 20500798 2010
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| 19 | KLK8
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| Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.
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| Yoshida S.
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| Biol Chem 391(4):375-80. Review.PMID: 20180635 2010
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| 20 | KLK10, KLK5, KLK7, KLK8
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| Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.
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| Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, Liu Y, Ravosa MJ, Frazier S, Stack MS.
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| Histol Histopathol 24(2):197-207.
2009
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| 21 | KLK8
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| Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory.
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| Lu ZX, Huang Q, Su B.
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| Cell Res 19(2):259-67.PMID: 19125171 2009
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| 22 | KLK8
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| Human kallikrein 8 expression in salivary gland tumors.
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| Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP.
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| Head Neck Pathol 2(3):169-74. Epub 2008 Jul 3.PMID: 20614312 2008
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| 23 | KLK8
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| A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.
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| Lu ZX, Peng J, Su B.
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| Hum Mutat 28(10):978-84. 2007
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| 24 | KLK5, KLK6, KLK8, KLK9
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| Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells.
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| Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J.
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| Cancer Sci 98(7):1078-86. Epub 2007 Apr 24.PMID: 17459052 2007
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| 25 | KLK8, SERPINB6
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| SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.
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| Scott FL, Sun J, Whisstock JC, Kato K, Bird PI.
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| J Biochem 142(4):435-42. Epub 2007 Aug 30.PMID: 17761692 2007
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| 26 | KLK13, KLK2, KLK3, KLK5, KLK6, KLK7, KLK8
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| Distribution of 15 human kallikreins in tissues and biological fluids.
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| Shaw JL, Diamandis EP.
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| Clin Chem 53(8):1423-32. Epub 2007 Jun 15.PMID: 17573418 2007
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| 27 | KLK8
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| Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
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| Sher YP, Chou CC, Chou RH, Wu HM, Wayne Chang WS, Chen CH, Yang PC, Wu CW, Yu CL, Peck K.
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| Cancer Res 66(24):11763-70. 2006
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| 28 | APOC-E@, APOC1, APOC4, APOE, KLK11, KLK8, NECTIN2
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| Analysis of Association at Single Nucleotide Polymorphisms in the APOE Region.
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| Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, Sipe CA, Grubber JM, Warren LL, Conneally PM, Saunders AM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance JM.
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| Genomics 63(1):7-12. 2000
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| 29 | KLK10, KLK11, KLK12, KLK13, KLK14, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| The New Human Kallikrein Gene Family: Implications in Carcinogenesis.
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| Diamandis EP, Yousef GM, Luo I, Magklara I, Obiezu CV.
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| Trends Endocrinol Metab 11(2):54-60. 2000
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| 30 | KLK1, KLK10, KLK11, KLK12, KLK13, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
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| Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA.
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| J Biol Chem 275(48):37397-406.
2000
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| 31 | KLK8
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| A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.
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| Mitsui S, et al.
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| Eur J Biochem 260(3):627-34 1999
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| 32 | KLK8
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| Sequence analysis and expression of human neuropsin cDNA and gene.
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| Yoshida S, et al.
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| Gene 213(1-2):9-16 1998
|