| basic FUNCTION
| acting as a serine-type endopeptidase |
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involved in the degradation of enamel proteins playing a critical role in enamel mineralisation |
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may play an important functional role in prostate cancer progression in addition to its biomarker potential |
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may play a role in tissue remodeling and cancer metastasis |
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exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates  |
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believed to play an essential role in enamel biomineralization, because defects in KLK4 cause hypomaturation amelogenesis imperfecta |
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essential for the removal of enamel proteins and the proper maturation of enamel crystals |
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principle functions of MMP20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins |
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AMTN and KLK4 function independently, but are both necessary for proper enamel maturation |
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MMP20 and KLK4 serve overlapping and complementary functions to harden enamel by removing protein, but MMP20 potentially serves multiple additional functions necessary for the adherence of enamel to dentin and the release of intercellular protein stores into the enamel matrix |
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HPN and TMPRSS2 colocalize on the cell surface with the secreted serine proteases KLK4 and KLK14, only in membrane protrusions, suggesting that reciprocal proteolytic interactions occur in defined cellular structures that are important during cancer dissemination for cell migration, invasion and survival |
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KLK3, KLK4, KLK11, and KLK2, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process |
