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FLASH GENE
Symbol KLK15 contributors: mct - updated : 10-12-2010
HGNC name kallikrein-related peptidase 15
HGNC id 20453
Location 19q13.33      Physical location : 51.328.545 - 51.334.779
Synonym name
  • prostinogen
  • ACO protease
  • kallikrein 15
  • Synonym symbol(s) HSRNASPH, ACO
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 6.23 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC284361 19q13.33-q13.41 hypothetical protein LOC284361 SBBI54 19q13.41 hypothetical transmembrane protein SBBI54 LOC284363 19q13.41 similar to RIKEN cDNA 0610012D14 DKFZp761A179 SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1309 - 256 - 2001 11010966
    4 - 1172 - 161 - 2001 11010966
    4 - 1054 - 171 - 2001 11010966
    - - - - - - 2005 15650036
  • also called KLK15 variant
  • KLK15 was up-regulated in cancerous prostate tissues
  • predicted to be truncated and catalytically inactive because of a lack of the serine residue of the catalytic triad
  • appears to be a candidate biomarker for prostate cancer
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly Homo sapiens
     salivary gland    
    Endocrineadrenal gland    
     thyroid   highly Homo sapiens
    Reproductivemale systemprostate  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion in breast milk and seminal plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • trypsin-like serine protease domain
  • signal peptide of 15AA
  • HOMOLOGY
    interspecies homolog to murine Prss20
    intraspecies homolog to klk11
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine protease that is produced in prostate and other tissues and is secreted in seminal plasma and other fluids
  • may have some utility as a prostate, ovarian, and breast cancer biomarker
  • exhibits significant activity towards both Arg- and Lys-containing KLK pro-sequences
  • can potentially feed back into additional pro-KLK activation pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in renal cell carcinoma (RCC)
    tumoral     --over  
    in prostate carcinoma, highly expressed in more aggressive tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLK15 expression analysis could be employed as a valuable tool for the discrimination between prostate cancer (CaP) and benign prostatic hyperplasia (BPH) tissue specimens and as an unfavorable prognostic marker for prostate cancer
  • might be useful as a biomarker for breast, ovarian, and prostate cancer
  • Therapy target
    ANIMAL & CELL MODELS