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FLASH GENE
Symbol KLK15 contributors: mct - updated : 16-04-2020
HGNC name kallikrein-related peptidase 15
HGNC id 20453
Location 19q13.33      Physical location : 51.328.545 - 51.334.779
Synonym name
  • prostinogen
  • ACO protease
  • kallikrein 15
  • Synonym symbol(s) HSRNASPH, ACO
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 9.05 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1325 - 256 - 2018 29928903
    - - - - - - 2018 29928903
  • also called KLK15 variant
  • KLK15 was up-regulated in cancerous prostate tissues
  • predicted to be truncated and catalytically inactive because of a lack of the serine residue of the catalytic triad
  • appears to be a candidate biomarker for prostate cancer
  • 5 - 1322 - 255 - 2018 29928903
    3 - 1185 - 160 - 2018 29928903
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly Homo sapiens
     salivary gland    
    Endocrinethyroid   highly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
     male systemprostate  moderately Homo sapiens
     male systemseminal vesicles  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion in breast milk and seminal plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • trypsin-like serine protease domain
  • signal peptide of 15AA
  • HOMOLOGY
    interspecies homolog to murine Prss20
    intraspecies homolog to klk11
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • displayed predominantly nuclear localization in the basal cell layer of the prostatic epithelium
  • basic FUNCTION
  • serine protease that is produced in prostate and other tissues and is secreted in seminal plasma and other fluids
  • may have some utility as a prostate, ovarian, and breast cancer biomarker
  • exhibits significant activity towards both Arg- and Lys-containing KLK pro-sequences
  • can potentially feed back into additional pro-KLK activation pathways
  • role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be able to cleave many extracellular matrix (ECM) components, similar to several members of the KLK family, and could potentially be linked to tumorigenesis by promoting metastasis via this mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in renal cell carcinoma (RCC)
    tumoral     --over  
    in prostate carcinoma, highly expressed in more aggressive tumors
    tumoral     --over  
    in prostate cancer cell lines and KLK15 expression was hormone-independent
    Susceptibility
  • to prostate cancer aggressiveness
  • Variant & Polymorphism SNP
  • KLK15 SNP rs2659056 was found to be associated with prostate cancer aggressiveness
  • Candidate gene
    Marker
  • KLK15 expression analysis could be employed as a valuable tool for the discrimination between prostate cancer (CaP) and benign prostatic hyperplasia (BPH) tissue specimens and as an unfavorable prognostic marker for prostate cancer
  • might be useful as a biomarker for breast, ovarian, and prostate cancer
  • KLK15 classical mRNA expression levels is a novel biomarker helpful for the differential diagnosis and prognosis of prostate cancer patients
  • biomarker potential for chromophobe renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS