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FLASH GENE
Symbol KLK15 contributors: mct - updated : 16-04-2020
HGNC name kallikrein-related peptidase 15
HGNC id 20453
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in renal cell carcinoma (RCC)
tumoral     --over  
in prostate carcinoma, highly expressed in more aggressive tumors
tumoral     --over  
in prostate cancer cell lines and KLK15 expression was hormone-independent
Susceptibility
  • to prostate cancer aggressiveness
  • Variant & Polymorphism SNP
  • KLK15 SNP rs2659056 was found to be associated with prostate cancer aggressiveness
  • Candidate gene
    Marker
  • KLK15 expression analysis could be employed as a valuable tool for the discrimination between prostate cancer (CaP) and benign prostatic hyperplasia (BPH) tissue specimens and as an unfavorable prognostic marker for prostate cancer
  • might be useful as a biomarker for breast, ovarian, and prostate cancer
  • KLK15 classical mRNA expression levels is a novel biomarker helpful for the differential diagnosis and prognosis of prostate cancer patients
  • biomarker potential for chromophobe renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS