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FLASH GENE
Symbol KLC3 contributors: mct - updated : 24-03-2022
HGNC name kinesin light chain 3
HGNC id 20717
Location 19q13.32      Physical location : 45.843.997 - 45.854.778
Synonym name
  • kinesin light chain 2-like
  • kinesin light chain 2
    • Synonym symbol(s) KLC2, KNS2B, KLCt, KLC2L,
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    STRUCTURE 10.78 kb     13 Exon(s)
    MAPPING cloned Y linked Y status provisional
    Map see ERCC2
    regionally located less than 300 bp proximal to the ERCC2 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1793 - 504 - 2001 11319135
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemovary   
     male systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal domain with heptad repeats typical of the rod domain of cytoskeletal proteins
  • a central and C terminal consisting of 6 TPR repeats of approximatively 21 aminoacids
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to purple sea urchin Spklc
    homolog to chimpanzee KLC3 (97.0pc)
    Homologene
    FAMILY
  • kinesin light chain family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    text elongating spermatid tail midpiece, localized in outer dense fibers and associating with mitochondria
    basic FUNCTION
  • playing a role in organelle transport
  • functioning in coupling cargo to the heavy chain or in the modulation of its ATPase activity
  • involved in binding cargo and regulating kinesin activity
  • could play a microtubule-independent role during formation of sperm tails
  • only known kinesin light chain expressed in post-meiotic male germ cells
  • KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • oligomeric complex composed of two heavy chains and two light chains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to microtubule
  • binding to ODF1
  • mitochondrial outer membrane porin protein VDAC2 is a KLC3 binding partner
  • LRGUK binding to KLC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of KLC3 was significantly higher in asthenozoospermic compared to non-asthenozoospermic individuals
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS