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FLASH GENE
Symbol KLC3 contributors: mct - updated : 24-03-2022
HGNC name kinesin light chain 3
HGNC id 20717
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
STRUCTURE 10.78 kb     13 Exon(s)
MAPPING cloned Y linked Y status provisional
Map see ERCC2
regionally located less than 300 bp proximal to the ERCC2 gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1793 - 504 - 2001 11319135
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Reproductivefemale systemovary   
 male systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain with heptad repeats typical of the rod domain of cytoskeletal proteins
  • a central and C terminal consisting of 6 TPR repeats of approximatively 21 aminoacids
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to purple sea urchin Spklc
    homolog to chimpanzee KLC3 (97.0pc)
    Homologene
    FAMILY
  • kinesin light chain family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    text elongating spermatid tail midpiece, localized in outer dense fibers and associating with mitochondria
    basic FUNCTION
  • playing a role in organelle transport
  • functioning in coupling cargo to the heavy chain or in the modulation of its ATPase activity
  • involved in binding cargo and regulating kinesin activity
  • could play a microtubule-independent role during formation of sperm tails
  • only known kinesin light chain expressed in post-meiotic male germ cells
  • KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • oligomeric complex composed of two heavy chains and two light chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to microtubule
  • binding to ODF1
  • mitochondrial outer membrane porin protein VDAC2 is a KLC3 binding partner
  • LRGUK binding to KLC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of KLC3 was significantly higher in asthenozoospermic compared to non-asthenozoospermic individuals
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS