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FLASH GENE
Symbol KIF22 contributors: mct/pgu - updated : 27-09-2016
HGNC name kinesin family member 22
HGNC id 6391
Corresponding disease
SEMDJL2 spondyloepimetaphyseal dysplasia with joint laxity 2
Location 16p11.2      Physical location : 29.802.057 - 29.816.706
Synonym name
  • kid, kinesin heavy chain-like DNA-binding protein 4
  • kinesin-like 4
  • origin of plasmid DNA replication-binding protein
    • Synonym symbol(s) KID, KNSL4, OBP, OBP1, OBP2, KNS4, hKID,OBP-1, OBP-2, SEMDJL2, A-328A3.2
    DNA
    TYPE functioning gene
    STRUCTURE 14.65 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2097 73.13 665 - 2005 16176979
    EXPRESSION
    Rna function KIF22 mRNA was detected in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal region similar to the motor domain of kinesin
  • ATP and microtules binding sites
  • a microtubule-binding and coiled-coil domains that are required to turn off the polar ejection force at anaphase
  • a nuclear localization signal (NLS) able to bind DNA in the C terminal region
    • HOMOLOGY
    interspecies homolog to murine Kif22 (82.6pc)
    homolog to rattus Kif22 (83.7pc)
    Homologene
    FAMILY
  • kinesin-like protein family
  • kinesin 10 family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • colocalizing with mitotic chromosomes and concentrated in the kinetochore at anaphase
  • division, cell cycle, M, anaphase
  • localizes to the boundaries of anaphase and telophase chromosomes
    • basic FUNCTION
  • involved in spindle formation and the movements of chromosome during mitosis and meiosis
  • role in metaphase alignment and maintenance
  • contributing to spindle morphogenesis by mediating spindle microtubules stabilization
  • important cargo of the importin-alpha/beta transport pathway
  • contributes to the shortening of the anaphase chromosome mass along the spindle axis, preventing the frmation of multinucleated cells
  • potential broader role in the synthesis of extracellular matrix rather than with a more restricted role in the hypertrophic zone, that would be a prelude to calcification and vascular invasion
  • likely involvement in chromosomal movement during cell division
  • KIF22 and KIF4A contribute independently to the rapid and correct attachment of chromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respectively
  • chromokinesins KIF22 and KIF4A promote efficient chromosome congression through the concerted generation of anti-poleward (AP) force and the regulation of spindle MT dynamics
  • provides the ejection force that is required to position the arms of chromosomes properly but is not essential for metaphase plate formation, and both together with KIF4A are required for chromosome congression to the metaphase plate
  • microtubule-dependent molecular motor protein with DNA-binding capacity
  • differential contributions of KIF22 and CENPE in chromosome congression in physiological conditions where stabilized microtubules are becoming increased
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
  • interacts with CHFR and controls genomic stability
  • FAM83D represents a novel interaction partner of the chromokinesin KIF22 that is required for the generation of polar ejection forces and chromosome congression
  • SIAH1 induces the degradation of Kid (KIF22), a chromokinesin protein implicated in the normal progression of mitosis and meiosis, by the ubiquitin proteasome pathway
  • CCDC25 is a direct transcriptional target of KIF22, and inhibition of KIF22 increased CCDC25 expression and cyclin-dependent kinase 1 (CDK1) activity, resulting in delayed mitotic exit
    • cell & other
    REGULATION
    Other phosphorylated upon DNA damage
    ubiquitination mediated by SIAH1
    loading on chromosome is mediated by GTP Ran and importin beta
    degraded by the APC/C
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMDJL2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through the transcriptional upregulation of CDC25C
    ANIMAL & CELL MODELS