SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| colocalizing with mitotic chromosomes and concentrated in the kinetochore at anaphase |
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division, cell cycle, M, anaphase |
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localizes to the boundaries of anaphase and telophase chromosomes |
basic FUNCTION
| involved in spindle formation and the movements of chromosome during mitosis and meiosis |
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role in metaphase alignment and maintenance |
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contributing to spindle morphogenesis by mediating spindle microtubules stabilization |
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important cargo of the importin-alpha/beta transport pathway |
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contributes to the shortening of the anaphase chromosome mass along the spindle axis, preventing the frmation of multinucleated cells |
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potential broader role in the synthesis of extracellular matrix rather than with a more restricted role in the hypertrophic zone, that would be a prelude to calcification and vascular invasion |
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likely involvement in chromosomal movement during cell division |
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KIF22 and KIF4A contribute independently to the rapid and correct attachment of chromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respectively |
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chromokinesins KIF22 and KIF4A promote efficient chromosome congression through the concerted generation of anti-poleward (AP) force and the regulation of spindle MT dynamics |
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provides the ejection force that is required to position the arms of chromosomes properly but is not essential for metaphase plate formation, and both together with KIF4A are required for chromosome congression to the metaphase plate |
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microtubule-dependent molecular motor protein with DNA-binding capacity |
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differential contributions of KIF22 and CENPE in chromosome congression in physiological conditions where stabilized microtubules are becoming increased |