| basic FUNCTION
| generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation  |
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demethylate histone lysine and arginine residues in an oxidative reaction that requires Fe(II) and alpha-ketoglutarate as cofactors |
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involved in regulation of transcription, DNA-dependent |
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demethylate H3K9me3 at pericentric heterochromatin in mammalian cells |
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demethylation of H3K9me3 in round spermatids is dispensable for spermatogenesis but possible defects in KDM4D-null elongating spermatids could be rescued by functional redundancy of the KDM4B demethylase |
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essential role in the estrogen signaling |
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KDM4A, KDM4B, KDM4C, catalyze demethylation of tri- and di-methylated forms of both histone H3 lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2) |
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expression of KDM4B is itself regulated in a hypoxia-inducible factor- and hypoxia-dependent manner, suggesting multiple ways in which oxygen levels regulate histone methylation |
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histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3 |
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required for sustained proliferation and survival of tumor cells, and its aberrant expression may contribute to the pathogenesis of gastric cancer |
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KDM4B and KDM6B promotes osteogenic differentiation of mesenchymal stem/stromal cells (MSCs) |
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KDM4Bis a DNA damage response (DDR) protein and overexpression of KDM4B may contribute to the failure of anti-cancer therapy that relies on the induction of DNA damage |
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role for KDM4B in mitochondrial apoptosis |
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regulatory effect exerted by KDM4B on tumor growth through the modulation of TP53 target genes |
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histone demethylase KDM4B promotes tumorigenesis by inducing retrotransposition and DNA damage |
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can function as a signal responsive trans-acting splicing factor and scaffold that recruits and stabilizes the spliceosome near the alternative exon, thus promoting its inclusion |
