Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KDM4B contributors: mct - updated : 17-04-2014
HGNC name lysine (K)-specific demethylase 4B
HGNC id 29136
Location 19p13.3      Physical location : 4.969.123 - 5.153.606
Synonym name
  • jumonji domain containing 2B
  • jmjC domain-containing histone demethylation protein 3B
  • Synonym symbol(s) KIAA0876, JHDM3B, FLJ44906, JMJD2B
    EC.number 1.14.11.-
    DNA
    TYPE functioning gene
    STRUCTURE 184.48 kb     23 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure GATA-binding sites within intron 6
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5675 121.8 1096 - 2008 18984585
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text differentiated and undifferentiated stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic Jumonji C (JmjC)2 domain
  • one JmjN domain
  • conserved dual PHD and Tudor domains in addition to its JmjC domains
  • HOMOLOGY
    interspecies homolog to murine Jmjd2b
    Homologene
    FAMILY
  • JMJD2 family
  • JHDM3 histone demethylase family
  • KDM4 histone demethylase subfamily
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,nucleus
    basic FUNCTION
  • generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation
  • demethylate histone lysine and arginine residues in an oxidative reaction that requires Fe(II) and alpha-ketoglutarate as cofactors
  • involved in regulation of transcription, DNA-dependent
  • demethylate H3K9me3 at pericentric heterochromatin in mammalian cells
  • demethylation of H3K9me3 in round spermatids is dispensable for spermatogenesis but possible defects in KDM4D-null elongating spermatids could be rescued by functional redundancy of the KDM4B demethylase
  • essential role in the estrogen signaling
  • KDM4A, KDM4B, KDM4C, catalyze demethylation of tri- and di-methylated forms of both histone H3 lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2)
  • expression of KDM4B is itself regulated in a hypoxia-inducible factor- and hypoxia-dependent manner, suggesting multiple ways in which oxygen levels regulate histone methylation
  • histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3
  • required for sustained proliferation and survival of tumor cells, and its aberrant expression may contribute to the pathogenesis of gastric cancer
  • KDM4B and KDM6B promotes osteogenic differentiation of mesenchymal stem/stromal cells (MSCs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of the H3K4-specific methyltransferase, the mixed-lineage leukemia (MLL) 2 complex
  • constitutes a key component of the estrogen signaling pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruited to ESR1 target sites, demethylates H3K9me3 and facilitates transcription of ER responsive genes including MYB, MYC and CCND1
  • physically associated with and an integral component of the H3K4 methyltransferase MLL2 complex
  • novel feed forward mechanism involving CEBPB and KDM4B in the regulation of mitotic clonal expansion by controlling cell cycle gene expression
  • KDM4B enzymatic activity is required to enhance AR transcriptional activity
  • HSP90AA1 interacts and stabilizes KDM4B protein
  • KDM4B play a critical role during inner ear invagination via modulating histone methylation of the direct target DLX3
  • cell & other
    REGULATION
    induced by hypoxia and HIF (induce transcription of the JMJD1A and JMJD2B genes leading to increased protein expression)
    Other transcriptionally regulated by ESR1
    regulated by both ESR1 and HIF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    is a viable therapeutic target in Prostate carcinoma
    cancerreproductivebreast
    potential therapeutic target in breast cancer
    ANIMAL & CELL MODELS