| 1 | GDDLM, KDM4B
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| Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects
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| Duncan AR, Vitobello A, Collins SC, Vancollie VE, Lelliott CJ, Rodan L, Shi J, Seman AR, Agolini E, Novelli A, Prontera P, Guillen Sacoto MJ, Santiago-Sim T, Trimouille A, Goizet C, Nizon M, Bruel AL, Philippe C, Grant PE, Wojcik MH, Stoler J, Genetti CA, van Dooren MF, Maas SM, Alders M, Faivre L, Sorlin A, Yoon G, Yalcin B, Agrawal PB.
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| Am J Hum Genet. Dec 3;107(6):1170-1177. doi: 10.1016/j.ajhg.2020.11.001. Epub 2020 Nov 23. 2020
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| 2 | KDM4B
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| Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy.
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| Sha J, Han Q, Chi C, Zhu Y, Pan J, Dong B, Huang Y, Xia W, Xue W.
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| J Cell Physiol. Mar;235(3):2129-2138. doi: 10.1002/jcp.29117. Epub 2019 Aug 29 2020
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| 3 | KDM4B
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| Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1.
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| Xiang Y, Yan K, Zheng Q, Ke H, Cheng J, Xiong W, Shi X, Wei L, Zhao M, Yang F, Wang P, Lu X, Fu L, Lu X, Li F.
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| Cancer Res Jan 1;79(1):86-98. doi: 10.1158/0008-5472.CAN-18-1310. Epub 2018 Nov 20 2019
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| 4 | KDM4B
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| Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.
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| Duan L, Chen Z, Lu J, Liang Y, Wang M, Roggero CM, Zhang QJ, Gao J, Fang Y, Cao J, Lu J, Zhao H, Dang A, Pong RC, Hernandez E, Chang CM, Hoang DT, Ahn JM, Xiao G, Wang RT, Yu KJ, Kapur P, Rizo J, Hsieh JT, Luo J, Liu ZP.
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| 2019
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| 5 | KDM4B, TP53
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| KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage.
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| Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ.
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| Nucleic Acids Res. Apr 20;45(7):3674-3692. doi: 10.1093/nar/gkw1281 2017
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| 6 | HAX1, KDM4B
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| KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
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| Li H, Yang X, Wang G, Li X, Tao D, Hu J, Luo X.
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| Oncotarget Sep 6;7(36):57866-57877. doi: 10.18632/oncotarget.11077. 2016
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| 7 | DLX3, KDM4B
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| Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression.
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| Uribe RA, Buzzi AL, Bronner ME, Strobl-Mazzulla PH.
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| J Cell Biol 211(4):815-27. doi: 10.1083/jcb.201503071.
2015
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| 8 | KDM4B, MYCN
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| The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.
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| Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM.
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| J Natl Cancer Inst. Apr 29;107(6):djv080. doi: 10.1093/jnci/djv080. Print 2015 Jun 2015
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| 9 | KDM4B
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| The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells.
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| Choi JH, Song YJ, Lee H.
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| Biochem Biophys Res Commun. Jan 24;456(4):872-8. doi: 10.1016/j.bbrc.2014.12.061. Epub 2014 Dec 19 2015
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| 10 | HSP90AA1, KDM4B
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| Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.
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| Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N.
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| J Biol Chem Biol Chem. 2013 Apr 15. [Epub ahead of print]
2013
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| 11 | KDM4B
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| The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.
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| Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN.
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| Nucleic Acids Res ucleic Acids Res. 2013 Feb 21. [Epub ahead of print]
2013
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| 12 | KDM4B
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| Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation
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| Young LC, McDonald DW, Hendzel MJ.
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| J Biol Chem. Jul 19;288(29):21376-21388. doi: 10.1074/jbc.M113.491514. Epub 2013 Jun 6. 2013
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| 13 | KDM4B, KDM6B
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| Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
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| Ye L, Fan Z, Yu B, Chang J, Al Hezaimi K, Zhou X, Park NH, Wang CY.
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| Cell Stem Cell 11(1):50-61. doi: 10.1016/j.stem.2012.04.009.
2012
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| 14 | CEBPB, KDM4B
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| Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes.
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| Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, Zhu H, Zhang YD, Liu Y, Liu Y, Wang KK, Tang QQ.
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| Cell Death Differ 19(12):1917-27. doi: 10.1038/cdd.2012.75. Epub 2012 Jun 22.
2012
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| 15 | KDM4B
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| Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.
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| Shi L, Sun L, Li Q, Liang J, Yu W, Yi X, Yang X, Li Y, Han X, Zhang Y, Xuan C, Yao Z, Shang Y.
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| Proc Natl Acad Sci U S A 108(18):7541-6. Epub 2011 Apr 18.
2011
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| 16 | KDM4A, KDM4B, KDM4C, KDM4D
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| Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
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| Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U.
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| J Biol Chem 286(48):41616-25. doi: 10.1074/jbc.M111.283689. Epub 2011 Sep 13.
2011
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| 17 | KDM4B, KDM4D
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| The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility.
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| Iwamori N, Zhao M, Meistrich ML, Matzuk MM.
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| Biol Reprod 84(6):1225-34. doi: 10.1095/biolreprod.110.088955. Epub 2011 Feb 3.
2011
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| 18 | KDM4B
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| Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.
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| Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H.
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| PLoS One 6(3):e17830. doi: 10.1371/journal.pone.0017830.
2011
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| 19 | KDM4B
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| Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer.
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| Li W, Zhao L, Zang W, Liu Z, Chen L, Liu T, Xu D, Jia J.
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| Biochem Biophys Res Commun 416(3-4):372-8. doi: 10.1016/j.bbrc.2011.11.045. Epub 2011 Nov 19.
2011
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| 20 | KDM4B
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| The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.
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| Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL.
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| Cancer Res 70(16):6456-66. doi: 10.1158/0008-5472.CAN-10-0413. Epub 2010 Aug 3.
2010
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| 21 | KDM4A, KDM4B, KDM4C
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| Identification of non-histone substrates for JMJD2A-C histone demethylases.
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| Ponnaluri VK, Vavilala DT, Putty S, Gutheil WG, Mukherji M.
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| Biochem Biophys Res Commun 390(2):280-4. doi: 10.1016/j.bbrc.2009.09.107. Epub 2009 Sep 30.
2009
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| 22 | KDM3A, KDM4B, KDM4C
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| The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.
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| Beyer S, Kristensen MM, Jensen KS, Johansen JV, Staller P.
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| J Biol Chem 283(52):36542-52. Epub 2008 Nov 4. 2008
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| 23 | KDM4A, KDM4B, KDM4C
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| Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.
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| Katoh Y, Katoh M.
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| Int J Mol Med 20(2):269-73. 2007
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| 24 | KDM4A, KDM4B, KDM4C, KDM4D
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| Diversity within the JMJD2 histone demethylase family.
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| Shin S, Janknecht R.
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| Biochem Biophys Res Commun 353(4):973-7. Epub 2006 Dec 27.
2007
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| 25 | KDM4A, KDM4B, KDM4C
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| Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
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| Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y.
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| Cell 125(3):467-81. Epub 2006 Apr 6. 2006
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| 26 | JMJD2E, JMJD2F, KDM4A, KDM4B, KDM4C, KDM4D
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| Identification and characterization of JMJD2 family genes in silico.
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| Katoh M, Katoh M.
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| Int J Oncol 24(6):1623-8. 2004
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