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FLASH GENE
Symbol KCNS3 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
HGNC id 6302
Location 2p24      Physical location : 18.059.944 - 18.114.224
Synonym name
  • Shab-related delayed-rectifier K+ channel alpha subunit 3
  • voltage-gated potassium channel protein Kv9.3
    • Synonym symbol(s) Kv9.3
    DNA
    TYPE functioning gene
    STRUCTURE 54.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D2S287 - D2S398 - ODC1 - DDEF2 - D2S168 - D2S131 - D2S139 - D2S312 - VSNL1 - KCNS3 - D2S375 - cen
    Authors GeneMap (99)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
    Respiratorylung    
    Visualeyelens   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY potassium channel family B,(SHAB) subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the voltage-dependent potassium ion permeability of excitable membranes
  • assuming opened or closed conformations in response to the voltage difference across the membrane
  • is a selective marker of parvalbumin (PV) neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heteromultimer with KCNB1 and with KCNB2
    INTERACTION
    DNA
    RNA
    small molecule
    protein KCNB1,KCNB2
    cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNS3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma (airway hyperesponsiveness)
    Variant & Polymorphism SNP associated with higher risk of asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS