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FLASH GENE
Symbol KCNS3 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
HGNC id 6302
DNA
TYPE functioning gene
STRUCTURE 54.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D2S287 - D2S398 - ODC1 - DDEF2 - D2S168 - D2S131 - D2S139 - D2S312 - VSNL1 - KCNS3 - D2S375 - cen
Authors GeneMap (99)
Physical map
DDX1 2p24.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 LOC130678 2p25.1 similar to 60S acidic ribosomal protein P1 NCYM 2p24.1 similar to 60S acidic ribosomal protein P1 MYCN 2p24.1 v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) LOC391353 2 similar to Cerebellar-degeneration-related antigen 1 (CDR34) DKFZP566A1524 2p24.3 hypothetical protein DKFZp566A1524 LOC391354 2 similar to Mothers against decapentaplegic homolog interacting protein (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP) LOC388925 2 hypothetical gene supported by BC018859; NM_002802 VSNL1 2p24.3 visinin-like 1 SMC6L1 2p24.3 SMC6 structural maintenance of chromosomes 6-like 1 (yeast) LOC388926 2 similar to RIKEN cDNA 5830483C08 gene FLJ40869 2p24.3 similar to RIKEN cDNA 5830483C08 gene LOC343930 2p24.3 similar to pMesogenin1 KCNS3 2p23-p22.2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 RDH14 2p24.1 retinol dehydrogenase 14 (all-trans and 9-cis) NT5C1B 2p24.1 5'-nucleotidase, cytosolic IB LOC388927 2 LOC388927 OSR1 3p22-p21.3 oxidative-stress responsive 1 LOC130500 2p24.3 similar to Uncharacterized hematopoietic stem/progenitor cells protein MDS029 LOC130502 2p24.3 similar to CG14894-PA KIAA1336 2p24.3 KIAA1336 protein MATN3 2p24-p23 matrilin 3 LAPTM4A 2p24.3 lysosomal-associated protein transmembrane 4 alpha LOC391355 2 similar to 40S ribosomal protein S16
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node    
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung    
Visualeyelens   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY potassium channel family B,(SHAB) subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the voltage-dependent potassium ion permeability of excitable membranes
  • assuming opened or closed conformations in response to the voltage difference across the membrane
  • is a selective marker of parvalbumin (PV) neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heteromultimer with KCNB1 and with KCNB2
    INTERACTION
    DNA
    RNA
    small molecule
    protein KCNB1,KCNB2
    cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNS3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma (airway hyperesponsiveness)
    Variant & Polymorphism SNP associated with higher risk of asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS