Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KCNS1

contributors: mct - updated : 24-06-2014

HGNC name	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
HGNC id	6300

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q12      Physical location : 43.720.950 - 43.729.753
Synonym name	delayed-rectifier K(+) channel alpha subunit 1
	voltage-gated potassium channel subunit Kv9.1
Synonym symbol(s)	KV9.1

DNA

TYPE	functioning gene
STRUCTURE	8.80 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KCNS1 5 - 4556 58.24 526 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex       brain diencephalon epithalamus habenula     brain diencephalon hypothalamus       spinal cord

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane protein with six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

heteromer , polymer

HOMOLOGY

interspecies

homolog to murine Kcns1

Homologene

FAMILY	potassium channel family
	S subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

basic FUNCTION

acting as regulatory a-subunit of Shab family voltage-gated K channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

modulator of KCNB1

cell & other

REGULATION

activated by

BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNS1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS