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FLASH GENE

Symbol

KCNH6

contributors: mct/npt - updated : 05-03-2014

HGNC name	potassium voltage-gated channel, subfamily H (eag-related), member 6
HGNC id	18862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q23.3      Physical location : 61.600.694 - 61.626.338
Synonym name	eag related protein 2
	ether-a-go-go related gene potassium channel 2
Synonym symbol(s)	ERG2, HERG2, Kv11.2

DNA

TYPE	functioning gene
STRUCTURE	25.64 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030779 14 splicing 3421 NP_110406 109.9 994 - 2004 15202000 NM_173092 15 splicing 3017 NP_775115 - 905 - 2004 15202000 lackng two internal segments NM_001278919 13 - 3783 NP_001265848 - 958 - 2004 15202000 NM_001278920 13 - 3650 NP_001265849 - 835 - 2004 15202000

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol nervous brain diencephalon       Nervous brain hindbrain cerebellum     Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines	prolactine adenoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal cytoplasmic domain with PAS (PER-ARNT-SIM) dimerization domain and PAC (PAS-associated C-terminal) domain
	six transmembrane domains the fourth being the voltage-sensor site
	a pore forming domain (H5) between the fifth and sixth transmembrane domains
	C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore

mono polymer

homomer , heteromer , tetramer

HOMOLOGY

Homologene

FAMILY	potassium channel family
	H (EAG) subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	pore forming (alpha) subunit of voltage-gated potassium channel
	forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)
	selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

text	prolactine secretion

PATHWAY

metabolism

signaling

a component	KCNH2, KCNH7
	part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	cyclic nucleotide (cAMP)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS